phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate | EMD Millipore FCMAB110P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate

catalog :

FCMAB110P

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

10H11.E12

The same clone is also sold as:

Cell Signaling Technology: 4526
Rockland Immunochemicals: 200-303-400, 200-306-400, 200-301-400
Abnova: MAB2401
BioLegend: 651201, 651203, 651204, 651202
Invitrogen: 14-9046-80, 50-9046-42, MA1-46069, 14-9046-37, 50-9046-41, 14-9046-82
LifeSpan Biosciences: LS-C2763, LS-C180288, LS-C180224, LS-C180223, LS-C180222
OriGene: TA309577
Abcam: ab36810
Novus Biologicals: NBP2-80586, NB100-306
Santa Cruz Biotechnology: sc-47739

reactivity :

human, mouse

application :

flow cytometry

citations: 13

Reference
Staquicini F, Qian M, Salameh A, Dobroff A, Edwards J, Cimino D, et al. Receptor tyrosine kinase EphA5 is a functional molecular target in human lung cancer. J Biol Chem. 2015;290:7345-59 pubmed publisher
Schmidt L, Wiedner M, Velimezi G, Prochazkova J, Owusu M, Bauer S, et al. ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress. DNA Repair (Amst). 2014;24:122-130 pubmed publisher
Soriani A, Iannitto M, Ricci B, Fionda C, Malgarini G, Morrone S, et al. Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1. J Immunol. 2014;193:950-60 pubmed publisher
Lin R, Ho C, Liu L, Lyu Y. Topoisomerase II? deficiency enhances camptothecin-induced apoptosis. J Biol Chem. 2013;288:7182-92 pubmed publisher
Zhang T, Penicud K, Bruhn C, Loizou J, Kanu N, Wang Z, et al. Competition between NBS1 and ATMIN controls ATM signaling pathway choice. Cell Rep. 2012;2:1498-504 pubmed publisher
Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response. Nucleic Acids Res. 2013;41:900-11 pubmed publisher
Conradt L, Henrich A, Wirth M, Reichert M, Lesina M, Algül H, et al. Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death. Int J Cancer. 2013;132:2248-57 pubmed publisher
Hasham M, Snow K, Donghia N, Branca J, Lessard M, Stavnezer J, et al. Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase. J Immunol. 2012;189:2374-82 pubmed publisher
Duxin J, Moore H, Sidorova J, Karanja K, Honaker Y, Dao B, et al. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. J Biol Chem. 2012;287:21980-91 pubmed publisher
Ondovcik S, Tamblyn L, McPherson J, Wells P. Oxoguanine glycosylase 1 (OGG1) protects cells from DNA double-strand break damage following methylmercury (MeHg) exposure. Toxicol Sci. 2012;128:272-83 pubmed publisher
Pampeno C, Hurtado A, Meruelo D. ATM kinase is activated by sindbis viral vector infection. Virus Res. 2012;166:97-102 pubmed publisher
Lee H, Trott J, Haque S, McCormick S, Chiorazzi N, Mongini P. A cyclooxygenase-2/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells. J Immunol. 2010;185:5300-14 pubmed publisher
Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, et al. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010;285:38534-42 pubmed publisher

product information

Catalog Number :

FCMAB110P

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13315

Host Name :

Mouse

Antigen :

phospho-ATM (Ser1981)

Clone :

10H11.E12

Conjugate :

Phycoerythrin

Isotype :

IgG1κ

Product Description :

Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12 PE conjugate

Cross Reactivity :

Human;Mouse;Rat

Background :

Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair. Mutation in the ATM gene results in the autosomal recessive disease ataxia telangiectasia (AT). The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1 and Chk1. The essential requirement for the substrates of ATM/ATR is S/TQ. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S/TQ are negative determinants for substrate phosphorylation. The complex phenotype of cells derived from patients with AT suggests that ATM has additional cellular substrates. In unirradiated cells, ATM is present as an inactive homodimer or multimer. Double-stranded breaks in DNA caused by ionizing radiation cause rapid ATM kinase activation through dissociation of this complex and ATM autophosphorylation at Ser1981.

ALT Names :

A-T, mutated AT mutated TEL1, telomere maintenance 1, homolog ataxia telangiectasia mutated ataxia telangiectasia mutated (includes complementation groups A, C and D) ataxia telangiectasia mutated protein human phosphatidylinositol 3-kinase homolog serine-protein kinase ATM

Immunogen :

KLH-conjugated, synthetic peptide corresponding to human ATM phosphorylated at Ser1981.

Specificity :

Antibody recognizes ATM phosphorylated at Ser1981.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. Protect from light.