phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor® 488 | EMD Millipore FCMAB108A4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor® 488

catalog :

FCMAB108A4

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

5D11G5

The same clone is also sold as:

Cell Signaling Technology: 4805

reactivity :

human, bovine

application :

western blot, flow cytometry

citations: 4

Reference
Schmidt L, Wiedner M, Velimezi G, Prochazkova J, Owusu M, Bauer S, et al. ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress. DNA Repair (Amst). 2014;24:122-130 pubmed publisher
Penicud K, Behrens A. DMAP1 is an essential regulator of ATM activity and function. Oncogene. 2014;33:525-31 pubmed publisher
Zhang T, Penicud K, Bruhn C, Loizou J, Kanu N, Wang Z, et al. Competition between NBS1 and ATMIN controls ATM signaling pathway choice. Cell Rep. 2012;2:1498-504 pubmed publisher
Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, et al. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010;285:38534-42 pubmed publisher

product information

Catalog Number :

FCMAB108A4

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor® 488

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q14683

Host Name :

Mouse

Antigen :

phospho-SMC1 (Ser957)

Clone :

5D11G5

Conjugate :

AlexaFluor®488

Isotype :

IgG1

Product Description :

Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor® 488

Cross Reactivity :

Human;Xenopus;Bovine

Background :

SMC (structural maintenance of chromosomes) proteins are Involved in chromosome cohesion during cell cycle and in DNA repair. ATM phosphorylates SMC1 on Ser957 and Ser966 both in vitro and in vivo. Phosphorylated SMC1 is part of the complex that functions as a downstream effector in both the ATM/NBS1 branch and the ATR/MSH2 branch of S-phase checkpoint.

ALT Names :

SMC1A SMCB SMC1alpha DXS423E DKFZp686L19178 SMC1 SMC1L1 Smcb OTTHUMP00000061876 KIAA0178 SB1.8 MGC138332 CDLS2 Sb1.8

Immunogen :

KLH-conjugated, synthetic peptide corresponding to human SMC1 phosphorylated at Ser957

Specificity :

Antibody recognizes SMC1 phosphorylolated at Ser957.

Package Size :

100 tests

Uses :

Western Blotting;Flow Cytometry

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. Protect from light.