PhosphoDetect™ Anti-ATM (pSer1981) Mouse mAb (10H11.E12) | EMD Millipore DR1002-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PhosphoDetect™ Anti-ATM (pSer1981) Mouse mAb (10H11.E12)

catalog :

DR1002-50UG

quantity :

50 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000; loading ...; fig 4b	Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed publisher

product information

Catalog Number :

DR1002-50UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

PhosphoDetect™ Anti-ATM (pSer1981) Mouse mAb (10H11.E12)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

472 (Hu), 11920 (Ms), 300711 (Rt)

Host Name :

Clone :

10H11.E12

Conjugate :

Purified

Isotype :

IgG1

Product Description :

PhosphoDetect™ Anti-ATM (pSer1981) Mouse mAb (10H11.E12)

Cross Reactivity :

Human, Mouse

Background :

ATM (ataxia telangiectasia mutated, ACC# NP_000042) is a member of the PI-3/PI-4 kinase family and is a central mediator of the cellular response to DNA damage and cellular stress. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. ATM is a regulator of numerous downstream proteins, including the tumor suppressor proteins, p53 and BRCA1, the checkpoint kinase, CHK2, the checkpoint proteins RAD17 and RAD9, and the DNA repair protein NBS1. ATM and the functionally related ATR kinase are thought to be master regulators of cell cycle checkpoint signaling pathways that are required for the cellular response to DNA damage and as well as genome stability. Activation of ATM in response to DNA damage requires intermolecular autophosphorylation of Ser1981 and dimer dissociation.

ALT Names :

AI256621, AT1, ATA, Ataxia telangiectasia, ATC, ATD, ATDC, ATE, C030026E19RIK, DKFZp781A0353, MGC74674, TEL1, TELO1, ataxia telangiectasia mutated

Immunogen :

a synthetic phosphopeptide (SLAFEEGpSQSTTISS) corresponding to amino acids 1974-1988 surrounding the Ser 1981 phosphorylation site of human ATM

Specificity :

Recognizes the ~370 kDa ATM protein phosphorylated at Ser 1981 .

Package Size :

50 ug

Uses :

WB, IC

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.