ICAM-1 (Ab-2) Mouse mAb (W-CAM-1) | EMD Millipore CP53-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ICAM-1 (Ab-2) Mouse mAb (W-CAM-1)

catalog :

CP53-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

CP53-100UG

Category :

Antibodies

Subcategory :

Cell Structure

Product Name :

Anti-ICAM-1 (Ab-2) Mouse mAb (W-CAM-1)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3383 (Hu), 15894 (Ms), 25464 (Rt)

Host Name :

Clone :

W-CAM-1

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-ICAM-1 (Ab-2) Mouse mAb (W-CAM-1)

Cross Reactivity :

Human

Background :

Cell adhesion molecules are membrane glycoproteins that play a major role in inflammation and neoplastic disease. Four primary groups of adhesion molecules have been described, which includes the integrin receptor family, the immunoglobulin superfamily, selectins, and cadherins. The intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) belong to the immunoglobulin superfamily that are the counter receptors for the leukocyte integrin, lymphocyte function associated antigen 1 (LFA-1, CD11a/CD18). ICAM-1 (CD54) is a single chain glycoprotein with 7 potential N-linked glycosylation sites. It is expressed in an inducible dependent manner by endothelial and epithelial cells as well as fibroblasts, macrophages, lymphocytes, and leukocytes. ICAM-1 can mediate adhesion by binding to CD11b/CD18 (Mac-1) enhancing antigen specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected erythrocytes distinct from the LFA-1 binding site.

ALT Names :

BB2, CD54, ICAM, INTERCELLULAR ADHESION MOLECULE 1, Ly-47, M90551, MALA-2, Melanoma Progression Associated Antigen, MGC6195, P3.58, intercellular adhesion molecule 1

Immunogen :

Raji cells

Specificity :

Recognizes the ~85-115 kDa ICAM-1 protein.

Package Size :

100 ug

Uses :

FUNC, FC, IH, WB, IF, IP

Storage :

Following initial use, aliquot and freeze (-20°C) for long-term storage if desired. Avoid freeze/thaw.