PSD-95 (Ab-2) Mouse mAb (7E3-1B8) | EMD Millipore CP35-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PSD-95 (Ab-2) Mouse mAb (7E3-1B8)

catalog :

CP35-100UL

quantity :

100 uL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; rat; fig 4 western blot; rat; 1:500; fig 4	Brigidi G, Santyr B, Shimell J, Jovellar B, Bamji S. Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Nat Commun. 2015;6:8200 pubmed publisher

product information

Catalog Number :

CP35-100UL

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-PSD-95 (Ab-2) Mouse mAb (7E3-1B8)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1742 (Hu), 13385 (Ms), 29495 (Rt)

Host Name :

Clone :

7E3-1B8

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-PSD-95 (Ab-2) Mouse mAb (7E3-1B8)

Cross Reactivity :

Rat

Background :

Effective synaptic transmission requires the precise distribution and spatial localization of neurotransmitter receptors and ion channels on the postsynaptic nerve terminal. An understanding of synaptic development is derived largely from studies of the vertebrate skeletal neuromuscular junction. At glutamatergic synapses, the membrane associated cytoskeletal protein PSD-95 (Post Synaptic Density 95kDa) is believed to promote receptor clustering via interactions with the NR2 subunit of the NMDA receptor and the Shaker-type potassium channel. These interactions are likely mediated by multiple repeating PDZ domains (90 amino acid repeats). Two additional proteins, homer and GRIP, have recently been shown to interact with the metabotropic and AMPA receptors, respectively. It is likely that these proteins serve major functions in the molecular scaffolding and signal transduction process, which occurs at the synaptic junction.

ALT Names :

DLGH4, FLJ97752, FLJ98574, PSD-95, PSD95/SAP90, SAP-90, SAP90A, discs, large homolog 4 (Drosophila)

Immunogen :

recombinant, rat PSD95

Specificity :

Recognizes the ~95 kDa PSD-95 protein.

Package Size :

100 uL

Uses :

WB, IF, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.