β-2 Microglobulin Antibody, clone C21 | EMD Millipore CBL306 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

β-2 Microglobulin Antibody, clone C21

catalog :

CBL306

quantity :

1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C21

The same clone is also sold as:

ImmuQuest: IQ424

reactivity :

human

citations: 1

Reference
Sreejit G, Ahmed A, Parveen N, Jha V, Valluri V, Ghosh S, et al. The ESAT-6 protein of Mycobacterium tuberculosis interacts with beta-2-microglobulin (Î²2M) affecting antigen presentation function of macrophage. PLoS Pathog. 2014;10:e1004446 pubmed publisher

product information

Catalog Number :

CBL306

Subcategory :

Inflammation & Immunology

Product Name :

Anti-β-2 Microglobulin Antibody, clone C21

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P61769

Host Name :

Mouse

Antigen :

β-2 Microglobulin

Clone :

C21

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-β-2 Microglobulin Antibody, clone C21

Cross Reactivity :

Human

Background :

Beta2 microglobulin is a 12 KDa protein with a pI of 5.6. Serum beta2 microglobulin levels are a reflection of cell turnover. Levels rise with fever, inflammation, and infection. Increased serum levels are also seen in B-cell malignancies and in renal failure and may indicate a worse prognosis for patients with early-stage Hodgkin's lymphoma. In urine, increased levels are seen in proximal renal tubular disease as well as renal transplant rejection. Beta2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumours and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy).

Specificity :

The antibody recognizes the "hidden determinant" of beta-2 microglobulin.

Package Size :

1 mg

Uses :

ELISA

Storage :

For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.