Keratin K3/K76 Antibody, clone AE5 | EMD Millipore CBL218-I product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Keratin K3/K76 Antibody, clone AE5

catalog :

CBL218-I

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

AE5

The same clone is also sold as:

Invitrogen: MA1-5763

reactivity :

rat, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; 1:100; fig 2e	Hazra S, Nandi S, Naskar D, Guha R, Chowdhury S, Pradhan N, et al. Non-mulberry Silk Fibroin Biomaterial for Corneal Regeneration. Sci Rep. 2016;6:21840 pubmed publisher

product information

Catalog Number :

CBL218-I

Subcategory :

Cell Signaling

Product Name :

Anti-Keratin K3/K76 Antibody, clone AE5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q29426

Host Name :

Mouse

Antigen :

KRT3

Clone :

AE5

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Keratin K3/K76 Antibody, clone AE5

Cross Reactivity :

Bovine, Rabbit

Background :

Cytokeratin 3, also known as 65kDa Cytokeratin or Keratin K3 is a specific keratin found primarily in the corneal epithelium and minorly in other epithelium like that of the esophagus. The corneal epithelium tissue forms the outermost layer of the cornea, which is the clear front covering of the eye. Keratins are divided into two primary types based upon their isoelectric mobility and size, acidic, or type 1:40-55kDa, and basic to neutral or type 2, 56-70kDa. Cytokeratin 3 is a type II cytokeratin. Type II cytokeratins form pairs with other cytokeratins. Cytokeratin 3 is expressed in the corneal epithelium with Cytokeratin 12. Together Cytokeratin 3 and Cytokeratin 12 form molecules known as intermediate filaments. These filaments assemble into strong networks that provide strength and resilience to the corneal epithelium. Mutations in Cytokeratin 3 have been associated with Meesmann's Corneal Dystrophy a disease characterized by fragility of the anterior corneal epithelium.

ALT Names :

65 kDa cytokeratin, Cytokeratin-3, CK-3, Keratin-3, K3, Type-II keratin Kb3

Immunogen :

Whole cells corresponding to Rabbit Keratin, type II cytosleletal 3.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry, Immunofluorescence

Storage :

Stable for 1 year at 2-8°C from date of receipt