This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Integrin β2 [CD18] Antibody
catalog :
CBL158
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MEM 48
reactivity :
human
application :
western blot, immunohistochemistry, flow cytometry, blocking or activating experiments
citations: 28
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; 1 ug/ml; loading ...
Healy L, Puy C, Fernandez J, Mitrugno A, Keshari R, Taku N, et al. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017;292:8616-8629 pubmed publisher
  • blocking or activating experiments; human; loading ...; fig 1e
Li L, Qi X, Sun W, Abdel Azim H, Lou S, Zhu H, et al. Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality. EMBO Mol Med. 2016;8:1340-1359 pubmed publisher
Huang T, Smith R, Bacos K, Song D, Faull R, Waldvogel H, et al. No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease. Acta Neuropathol Commun. 2020;8:77 pubmed publisher
Ekman F, Ojala D, Adil M, Lopez P, Schaffer D, Gaj T. CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model. Mol Ther Nucleic Acids. 2019;17:829-839 pubmed publisher
Ochaba J, Fote G, Kachemov M, Thein S, Yeung S, Lau A, et al. IKKβ slows Huntington's disease progression in R6/1 mice. Proc Natl Acad Sci U S A. 2019;116:10952-10961 pubmed publisher
Zhao Q, Busch B, Jiménez Soto L, Ishikawa Ankerhold H, Massberg S, Terradot L, et al. Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation. PLoS Pathog. 2018;14:e1007359 pubmed publisher
Yau R, Doerner K, Castellanos E, Haakonsen D, Werner A, Wang N, et al. Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control. Cell. 2017;171:918-933.e20 pubmed publisher
Brilha S, Wysoczanski R, Whittington A, Friedland J, Porter J. Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin ?V?3 in Mycobacterium tuberculosis Infection. J Immunol. 2017;199:982-991 pubmed publisher
Ashkenazi A, Bento C, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, et al. Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature. 2017;545:108-111 pubmed publisher
Gasset Rosa F, Chillon Marinas C, Goginashvili A, Atwal R, Artates J, Tabet R, et al. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron. 2017;94:48-57.e4 pubmed publisher
Wade B, Wang C, Yan S, Bhat K, Huang B, Li S, et al. Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues. J Neurosci. 2014;34:8411-22 pubmed publisher
Valor L, Guiretti D, Lopez Atalaya J, Barco A. Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease. J Neurosci. 2013;33:10471-82 pubmed publisher
Lotz G, Weiss A. Immuno-based detection assays to quantify distinct mutant huntingtin conformations in biological samples. Methods Mol Biol. 2013;1017:163-71 pubmed publisher
Horne E, Coy J, Swinney K, Fung S, Cherry A, Marrs W, et al. Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models. Eur J Neurosci. 2013;37:429-40 pubmed publisher
Waldron Roby E, Ratovitski T, Wang X, Jiang M, Watkin E, Arbez N, et al. Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin. J Neurosci. 2012;32:183-93 pubmed publisher
Roscic A, Baldo B, Crochemore C, Marcellin D, Paganetti P. Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model. J Neurochem. 2011;119:398-407 pubmed publisher
Liang Q, Ouyang X, Schneider L, Zhang J. Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons. Mol Neurodegener. 2011;6:37 pubmed publisher
Zadori D, Nyiri G, Szonyi A, Szatmari I, Fulop F, Toldi J, et al. Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease. J Neural Transm (Vienna). 2011;118:865-75 pubmed publisher
Rising A, Xu J, Carlson A, Napoli V, Denovan Wright E, Mandel R. Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats. Exp Neurol. 2011;228:173-82 pubmed publisher
Zeituni A, Jotwani R, CARRION J, Cutler C. Targeting of DC-SIGN on human dendritic cells by minor fimbriated Porphyromonas gingivalis strains elicits a distinct effector T cell response. J Immunol. 2009;183:5694-704 pubmed publisher
McKillop W, Barrett J, Pasternak S, Chan B, Dekaban G. The extracellular domain of CD11d regulates its cell surface expression. J Leukoc Biol. 2009;86:851-62 pubmed publisher
Weiss A, Roscic A, Paganetti P. Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction. Mol Neurodegener. 2009;4:11 pubmed publisher
Narayanan K, Irmady K, Subramaniam S, Unsicker K, Von Bohlen Und Halbach O. Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death. Neurosci Lett. 2008;446:117-22 pubmed publisher
Wang J, Wang C, Orr A, Tydlacka S, Li S, Li X. Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. J Cell Biol. 2008;180:1177-89 pubmed publisher
Weiss A, Klein C, Woodman B, Sathasivam K, Bibel M, Regulier E, et al. Sensitive biochemical aggregate detection reveals aggregation onset before symptom development in cellular and murine models of Huntington's disease. J Neurochem. 2008;104:846-58 pubmed
Smith M, Bivins Smith E, Tilley A, Bentz G, Chan G, Minard J, et al. Roles of phosphatidylinositol 3-kinase and NF-kappaB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistence. J Virol. 2007;81:7683-94 pubmed
Takeda Y, Tachibana I, Miyado K, Kobayashi M, Miyazaki T, Funakoshi T, et al. Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol. 2003;161:945-56 pubmed
Brdicka T, Pavlistová D, Leo A, Bruyns E, Korinek V, Angelisova P, et al. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 2000;191:1591-604 pubmed
product information
Catalog Number :
CBL158
Subcategory :
Cell Structure
Product Name :
Anti-Integrin β2 [CD18] Antibody
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P05107
Host Name :
Mouse
Antigen :
Integrin β2 [CD18]
Clone :
MEM 48
Conjugate :
Purified
Isotype :
IgG1
Product Description :
Anti-Integrin β2 [CD18] Antibody
Cross Reactivity :
Human
ALT Names :
CD18
Immunogen :
Leucocytes from an LGL - type leukaemia
Specificity :
This antibody recognizes the CD18 molecule, a 95 kDa integrin molecule (beta 2 integrin) that forms the common beta chain of the CD11/CD18 heterodimer integrins which are expressed on all leucocytes. The beta2 integrin is the ICAM 1 receptor FUSION PARTNER: Sp 2/0 - Ag 14 myeloma cell line
Package Size :
100 µg
Uses :
Flow Cytometry;Western Blotting;Immunohistochemistry;Affects Function
Storage :
Maintain at 2o-8oC for up to 12 months from date of receipt. For long term storage aliquot antibody into small volumes and store at -20°C for up to one year.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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