BL-CAM Antibody, clone RFB4 | EMD Millipore CBL147 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BL-CAM Antibody, clone RFB4

catalog :

CBL147

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

RFB4

The same clone is also sold as:

Absolute Antibody: Ab00606-23.0, Ab00606-1.1
Invitrogen: MHCD2201, MHCD2205, MHCD2204, MHCD2204-4
LifeSpan Biosciences: LS-C134334, LS-C346751, LS-C201965, LS-C347408, LS-C134333, LS-C134332, LS-C134335, LS-C122971, LS-C146585, LS-C134336
Abcam: ab23620, ab112182
OriGene: AM00647RP-N
Santa Cruz Biotechnology: sc-7307

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	de Hair M, van de Sande M, Ramwadhdoebe T, Hansson M, Landewe R, van der Leij C, et al. Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis. Arthritis Rheumatol. 2014;66:513-22 pubmed publisher
	Du X, Beers R, FitzGerald D, Pastan I. Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity. Cancer Res. 2008;68:6300-5 pubmed publisher

product information

Catalog Number :

CBL147

Subcategory :

Inflammation & Immunology

Product Name :

Anti-BL-CAM Antibody, clone RFB4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P20273

Host Name :

Mouse

Antigen :

BL-CAM

Clone :

RFB4

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-BL-CAM Antibody, clone RFB4

Cross Reactivity :

Human

ALT Names :

CD22

Immunogen :

Human tonsil lymphocytes

Specificity :

The CD22 antigen is a heterodimer composed of two glycoprotein chains of 130-140 kDa and is present as both a cytoplasmic and membrane antigen on B lymphocytes. Antigen expression appears at an early stage in B lymphocyte differentiation at approximately the same stage as the CD19 antigen. Surface expression of the CD22 antigen by B lymphocytes is variable. Circulating B lymphocytes are CD22 positive and follicular mantle and marginal zone B lymphocytes show strong binding of this antibody. Germinal centre B cells exhibit only weak expression of the CD22 antigen. The CD22 antigen is poorly expressed by non T ALL cells and by a proportion of B CLL cells. Hairy cell leukaemia cells have been demonstrated to strongly express the CD22 antigen. CD22 functions as a sialic acid binding lectin specifically sialic acid in alpha-2,6 linkage. Sialylation of CD22 by alpha-2,6 sialyl transferase inhibits CD22 ligand binding. Antigen distribution: B cells (lg+, E-) 92 + 3% Peripheral blood lymphocytes 12 + 3% Thymocytes 1% Granulocytes 1% Monocytes 1% T cells (E+) 1% FUSION PARTNER: NS1 myeloma cell line

Package Size :

100 µg

Uses :

Flow Cytometry;Immunofluorescence;Immunoprecipitation;Immunohistochemistry

Storage :

For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.