p19ARF (54-75) Rat mAb (5-C3-1) | EMD Millipore CB1012-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p19ARF (54-75) Rat mAb (5-C3-1)

catalog :

CB1012-50UG

quantity :

50 ug

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

CB1012-50UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p19ARF (54-75) Rat mAb (5-C3-1)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1029 (Hu), 12578 (Ms), 25163 (Rt)

Host Name :

Clone :

5-C3-1

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-p19ARF (54-75) Rat mAb (5-C3-1)

Cross Reactivity :

Mouse

Background :

In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This suggests that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various oncoproteins via the p53 regulatory loop. These studies and others demonstrate the importance of p19ARF in cell cycle control and tumor suppression.

ALT Names :

ARF, ARF-INK4a, CDK4I, CDKN2, CMM2, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, INK4, INK4A, INK4a-ARF, Ink4a/Arf, MLM, MTS1, p14, p14/ARF, p14ARF, P16, p16(INK4a), p16Cdkn2a, p16INK4, P16INK4A, p19, p19ARF, PCTR1, TP16

Immunogen :

a synthetic peptide corresponding to amino acids 54-75 of mouse p19 ARF

Specificity :

Recognizes the ~19 kDa p19 ARF protein.

Package Size :

50 ug

Uses :

WB, IF, IP, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.