TBK1 Mouse mAb (108A429) | EMD Millipore AM76-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TBK1 Mouse mAb (108A429)

catalog :

AM76-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

AM76-100UG

Category :

Antibodies

Subcategory :

Inflammation & Immunology

Product Name :

Anti-TBK1 Mouse mAb (108A429)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

29110 (Hu), 56480 (Ms), 299827 (Rt)

Host Name :

Clone :

108A429

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-TBK1 Mouse mAb (108A429)

Cross Reactivity :

Human

Background :

Nuclear factor kappaB (NF-kappaB) is sequestered in cell cytoplasm by the IkappaB family of inhibitory proteins that mask the nuclear localization signal of NF-kappaB, preventing its translocation to the nucleus. Stimulus by tumor necrosis factor or other cytokines results in the phosphorylation and degradation of IkappaB, releasing NF-kappaB dimers. These dimers then translocate to the nucleus and activate target genes. IkappaBalpha synthesis is autoregulated. IkappaB proteins are phosphorylated by an IkappaB kinase made up of at least three proteins; IKK1/alpha, IKK2/beta, and IKK3/ɣ. IKK 1/alpha and IKK2/beta are phosphorylated by NF-kappaB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1) respectively. TANK-binding kinase (TBK1) has recently been identified as a member of the IKK family. TRAF-associated NF-kappaB activator (TANK) interacts with TBK1 and activates NF-kappaB in a kinase-dependent manner.

ALT Names :

NAK, T2K, Tbk, Tbk1 predicted, TANK-binding kinase 1

Immunogen :

full-length, recombinant, human TBK1 fused to a His•Tag ® sequence

Specificity :

Recognizes the ~80 kDa TBK1 protein.

Package Size :

100 ug

Uses :

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.