Mcl-1 (Ab-1) Mouse mAb (RC13) | EMD Millipore AM50-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Mcl-1 (Ab-1) Mouse mAb (RC13)

catalog :

AM50-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

Catalog Number :

AM50-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Mcl-1 (Ab-1) Mouse mAb (RC13)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

4170 (Hu), 17210 (Ms), 60430 (Rt)

Host Name :

Clone :

RC13

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Mcl-1 (Ab-1) Mouse mAb (RC13)

Cross Reactivity :

Human

Background :

Mcl-1 also known as myeloid cell leukemia-1 was originally identified as an early gene expressed in ML-1 cells during phorbol ester induced differentiation along the monocyte/macrophage pathway. Mcl-1 is a member of the bcl-2 family of apoptosis markers and is the anti-apoptotic homologue of bcl-2. The C-terminal regions of Mcl-1 and bcl-2 share significant sequence homology. Mcl-1 together with bcl-2 and the pro-apoptotic protein, bax are thought to function by forming homo- and heterotypic dimers that are critical in controlling the apoptotic process. Like bcl-2, Mcl-1 can be found in epithelial cells in a variety of tissues including prostate, breast, endometrium, epidermis, stomach, intestine colon and respiratory tract although with different expression patterns. Interestingly, in contrast to bcl-2, little or no Mcl-1 is detected in neurons of the brain and spinal cord however, Mcl-1 is highly expressed in cardiac and skeletal muscle which contain relatively less bcl-2.

ALT Names :

AW556805, BCL2L3, EAT, MCL1L, MCL1S, MGC104264, MGC1839, TM, myeloid cell leukemia sequence 1 (BCL2-related)

Immunogen :

a recombinant protein consisting of amino acids 1-327 of human Mcl-1

Specificity :

Recognizes the ~42 kDa Mcl-1 protein.

Package Size :

100 ug

Uses :

WB, IP

Storage :

For long-term storage, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.