Caspase-8 (Ab-3) Mouse mAb (1-3) | EMD Millipore AM46-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase-8 (Ab-3) Mouse mAb (1-3)

catalog :

AM46-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

AM46-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase-8 (Ab-3) Mouse mAb (1-3)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

841 (Hu), 12370 (Ms), 64044 (Rt)

Host Name :

Clone :

1-3

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Caspase-8 (Ab-3) Mouse mAb (1-3)

Cross Reactivity :

Human

Background :

Caspase-8 (ICE-LAP5, MACH, FLICE, CAP4) is the most proximal of the members of the apoptotic caspase cascade. Caspase-8 is directly involved in apoptosis mediated through either Fas or the TNF receptor and forms one of the key components of the transducing DISC, the CAP4 protein. Cell lines that are deficient in caspase-8 are resistant to Fas mediated apoptosis. Nine different isoforms of caspase 8 have been identified but the ""a"" and ""b"" isoforms show the highest expression at the level of protein in multiple tissues. Caspase-8 has a pH optimum of 6.8 and has a kcat/Km of 8.7 X 105 M-1 s-1. The pro-form of caspase-8 has a molecular weight of approximately 55 kDa and undergoes several processing steps to generate the active heterodimer of p18 and p10/12. In addition to activation via Fas, oligomerization of caspase-8 at the cell membrane and interaction with Granzyme B and caspase 10 will induce auto-processing and activation of the apoptotic pathway.

ALT Names :

ALPS2B, CAP4, CASPASE-8, FLICE, FLJ17672, MACH, MCH5, MGC78473, PROCASP8, caspase 8, apoptosis-related cysteine peptidase

Immunogen :

human recombinant caspase-8

Specificity :

Recognizes the ~56-58 kDa latent and the ~18 kDa active form of caspase-8.

Package Size :

100 ug

Uses :

Storage :

Do not freeze