Caspase-3 (Ab-2) Mouse mAb (10C1.C9) | EMD Millipore AM34-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase-3 (Ab-2) Mouse mAb (10C1.C9)

catalog :

AM34-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

AM34-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase-3 (Ab-2) Mouse mAb (10C1.C9)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

836 (Hu), 12367 (Ms), 25402 (Rt)

Host Name :

Clone :

10C1.C9

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Caspase-3 (Ab-2) Mouse mAb (10C1.C9)

Cross Reactivity :

Human

Background :

Caspase-3 (CPP32/Yama/Apopain) exists as a 32 kDa inactive precursor protein in the cytoplasm of most cell types. Upon proteolytic activation the protein is cleaved at a specific site within the molecule to yield a heterodimer consisting of p20 and p11 subunits. The cleavage/activation proceeds in two steps yielding first a p3 fragment followed by the p20 and p11 fragments and is mediated by specific proteases, including serine proteases and the enzyme granzyme B. Activation of CPP32 occurs rather rapidly following the onset of apoptosis induced by a number of different signals including, but not restricted to, TGFbeta1, TNF, and Fas. One of the most potent chemical activators of CPP32 is staurosporine. Once activated, CPP32 has a number of substrates; among those which have been reported are MDM2, PITSLRE kinases, actin, DNA-PK, and PARP. Related to the C. elegans protein Ced-3, CPP32 has been mapped in humans to chromosome 4q33-q35.1.

ALT Names :

Apopain, CASPASE-3, CASPASE-3 p20, CC3, CPP32, CPP32B, Cpp32beta, Ice-like cysteine protease, Lice, MGC93645, mldy, P17, PROCASPASE 3, SCA-1, YAMA, caspase 3, apoptosis-related cysteine peptidase

Immunogen :

full-length, recombinant, human caspase-3

Specificity :

Recognizes the ~32, ~28, and ~17 kDa forms of caspase-3.

Package Size :

100 ug

Uses :

Storage :

Do not freeze