PARP-1 (Ab-2) Mouse mAb (C-2-10) | EMD Millipore AM30-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PARP-1 (Ab-2) Mouse mAb (C-2-10)

catalog :

AM30-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:200; fig 5	He P, Bo S, Chung P, Ahn J, Zhou L. Photosensitizer effect of 9-hydroxypheophorbide ? on diode laser-irradiated laryngeal cancer cells: Oxidative stress-directed cell death and migration suppression. Oncol Lett. 2016;12:1889-1895 pubmed
western blot; human	Pourteymour S, Lee S, Langleite T, Eckardt K, Hjorth M, BindesbÃ¸ll C, et al. Perilipin 4 in human skeletal muscle: localization and effect of physical activity. Physiol Rep. 2015;3: pubmed publisher
western blot; human; 1:1000; fig 5d	Iansante V, Choy P, Fung S, Liu Y, Chai J, Dyson J, et al. PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation. Nat Commun. 2015;6:7882 pubmed publisher
	ZIMMERMAN B, Sargeant A, Landes K, Fernandez S, Chen C, Lairmore M. Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma. Leuk Res. 2011;35:1491-7 pubmed publisher

product information

Catalog Number :

AM30-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-PARP-1 (Ab-2) Mouse mAb (C-2-10)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

142 (Hu), 11545 (Ms), 25591 (Rt)

Host Name :

Clone :

C-2-10

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-PARP-1 (Ab-2) Mouse mAb (C-2-10)

Cross Reactivity :

Hamster, Human, Monkey, Mouse, Rat

Background :

PARP (Poly (ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase; NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] is a highly conserved nuclear enzyme present in higher eukaryotes. The enzyme is a Zn2+ dependent DNA binding protein that recognizes DNA strand breaks and is implicated in DNA repair and in the apoptotic response of cells. The critical functional domains of the protein are the DNA binding domain and the automodification domains. PARP functions by adding poly (ADP-ribose), in an ATP and NAD+ dependent manner, to various proteins in response to DNA damage and has been shown to directly interact with DNA polymerase alpha. As a marker for apoptosis, PARP cleavage has been variably shown to occur early in the response as a result of the activity of CPP32 (caspase-3, CASP3).

ALT Names :

5830444G22Rik, Adprp, Adprp1, ADPRT, ADPRT1, AI893648, C80510, MGC93658, PADPRT, pADPRT-1, PARP, PARS, POLY(ADP-RIBOSE) POLYMERASE 1, PPOL, sPARP-1, poly (ADP-ribose) polymerase 1

Immunogen :

purified PARP (poly(ADP-ribose) polymerase) from calf thymus

Specificity :

Recognizes the ~116 kDa full length and the ~85 kDa cleaved forms of PARP.

Package Size :

100 ug

Uses :

WB, IF

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.