Bak (Ab-2) Mouse mAb (TC-102) | EMD Millipore AM04-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Bak (Ab-2) Mouse mAb (TC-102)

catalog :

AM04-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

citations: 1

Reference
Haigis K, Kendall K, Wang Y, Cheung A, Haigis M, Glickman J, et al. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008;40:600-8 pubmed publisher

product information

Catalog Number :

AM04-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Bak (Ab-2) Mouse mAb (TC-102)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

578 (Hu), 12018 (Ms), 116502 (Rt)

Host Name :

Clone :

TC-102

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-Bak (Ab-2) Mouse mAb (TC-102)

Cross Reactivity :

Human, Mouse

Background :

Bak (for bcl-2 homologous antagonist/killer) is a member of the bcl-2 family of proteins. It was independently identified by three different groups using either the two hybrid system for identifying adenovirus E1B 19K interacting proteins or by PCR cloning using degenerate BH1 and BH2 domain primers derived from the human bcl-2 gene. Bak shows a 53% homology with bcl-2 in the BH1 and BH2 domains but an overall homology of 28% with bcl-2. The presence of a hydrophobic tail on the protein suggests that, like bcl-2, it is membrane localized. The bak protein is translated from a 2.2 kb mRNA to yield a 211-216 amino acid protein with a predicted molecular weight of 23.4 kDa, but which migrates by gel electrophoresis as an approximately 30 kDa protein under denaturing conditions. Bak is expressed widely in many tissues including heart, thymus, and colon. The bak gene (bak-1) has been mapped to chromosome 6 and spans approximately 6 kb of DNA3.

ALT Names :

BAK, BAK-LIKE, BCL2L7, CDN1, MGC108627, MGC117255, MGC3887, N-Bak, N-BAK1, BCL2-antagonist/killer 1

Immunogen :

human recombinant Bak protein from which the C-terminal and transmembrane domains have been deleted

Specificity :

Recognizes the ~30 kDa (apparent MW) Bak protein.

Package Size :

100 ug

Uses :

WB, IF

Storage :

Do not freeze