SEPT7 Antibody | EMD Millipore ABT354 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SEPT7 Antibody

catalog :

ABT354

quantity :

150 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 6e	Toriyama M, Toriyama M, Wallingford J, Finnell R. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. FASEB J. 2017;31:3622-3635 pubmed publisher
	Blum W, Pecze L, Rodriguez J, Steinauer M, Schwaller B. Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter. BMC Cancer. 2018;18:475 pubmed publisher

product information

Catalog Number :

ABT354

Subcategory :

Cell Structure

Product Name :

Anti-SEPT7 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q16181

Host Name :

Rabbit

Antigen :

Sept 7

Conjugate :

Affinity Purified

Product Description :

Anti-SEPT7 Antibody

Cross Reactivity :

Human

Background :

The protein Septin-7 or alternatively named CDC10 and encoded by the human gene named SEPT7 or CDC10 is a filament-forming cytoskeletal GTPase. SEPT7 is a member of the septin family, which is a highly conserved subfamily of GTPases implicated in exocytosis, apoptosis, synaptogenesis, neurodegeneration, and tumorigenesis. SEPT7 is required for normal organization of the actin cytoskeleton and required for normal progress through mitosis, meiosis, and cytokinesis. SEPT7 is also required for normal association of centromere protein E (CENPE) with the kinetochore at cytokinesis. CENPE is one of the motors that drive chromosomal movement and SEPT7 provides the molecular energy via the hydrolysis of GTP. Finally SEPT7 also operates in ciliogenesis and collective cell movements. Widely expressed by a variety of cells, SEPT7 is localized to the cytoplasm and to the typical structures seen during cytokinesis as well; SEPT7 is also found in cilium and axoneme and associated with other cytoskeletal elements and spindle apparatus. Anti-SEPT7 rabbit polyclonal antibody has been tested in western blot on Jurkat cell extracts and in paraffin embedded immunohistochemistry on human lung cancer tissue sections.

ALT Names :

Septin-7;CDC10 protein homolog

Immunogen :

GST-tagged fusion protein corresponding to human SEPT7.

Package Size :

150 µL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.