Dynamin related protein 1 (Drp1) Antibody | EMD Millipore ABT155 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Dynamin related protein 1 (Drp1) Antibody

catalog :

ABT155

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000; fig 3C	Sin J, Andres A, Taylor D, Weston T, Hiraumi Y, Stotland A, et al. Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts. Autophagy. 2016;12:369-80 pubmed publisher
	Sin J, McIntyre L, Stotland A, Feuer R, Gottlieb R. Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes. J Virol. 2017;91: pubmed publisher

product information

Catalog Number :

ABT155

Subcategory :

Cell Structure

Product Name :

Anti-Dynamin related protein 1 (Drp1) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8K1M6

Host Name :

Rabbit

Antigen :

Dynamin related protein 1 (Drp1)

Conjugate :

Affinity Purified

Product Description :

Anti-Dynamin related protein 1 (Drp1) Antibody

Cross Reactivity :

Human;Mouse;Rat;Ox;Rhesus Macaque

Background :

Dynamin related protein 1 (Drp1), also known as Dynamin-like protein 1, mediates outter mitochondrial membrane fission in mammilian cells. Like other members of the Dynamin superfamily of GTPases, Drp1 contains a N-terminal tripartate GTP-binding domain and exists as a T-shaped dimer with a head, leg, and stalk. The addition of GTP induces head and stalk rearrangement resulting in membrane constriction. Drp1 has been shown to affect mitochondrial morphology and places a significant role in mitochondrial and peroxisomal fission in mammilian cells. During apoptosis, Drp1 translocates from the cytosol to mitochondria and localizes to potential organelle division sites. Studies show Drp1 inhibition averts cell death, reinforcing to the critical role that mitochondrial fission plays in apoptosis.

ALT Names :

Dynamin-1-like protein;Dynamin family member proline-rich carboxyl-terminal domain less;Dymple;Dynamin-related protein 1

Immunogen :

KLH-conjugated linear peptide corresponding to the GSK3B interaction domain of mouse Dynamin related protein 1 (Drp1).

Specificity :

This antibody recognizes Dynamin related protein 1 (Drp1) at the GSK3B interaction domain.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt