phospho-FAK (Tyr397) Antibody | EMD Millipore ABT135 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-FAK (Tyr397) Antibody

catalog :

ABT135

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, chicken

application :

western blot, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig 7e	Chia J, Zhu T, Chyou S, Dasoveanu D, Carballo C, Tian S, et al. Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis. J Clin Invest. 2016;126:4331-4345 pubmed publisher

product information

Catalog Number :

ABT135

Subcategory :

Cell Structure

Product Name :

Anti-phospho-FAK (Tyr397) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q05397

Host Name :

Rabbit

Antigen :

phospho-FAK (Tyr397)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-FAK (Tyr397) Antibody

Cross Reactivity :

Rat;Human;Xenopus;Chicken;Mouse

Background :

Focal adhesion kinase (FAK) is a non receptor protein tyrosine kinase discovered as a substrate for Src and a key element in integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine is generally associated with positive regulation and growth promotion; however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis and may play a role in focal adhesion disassembly. FAK and its phosphorylation states have been implicated in cancer metastasis, tumor cell survival, and adhesion-independent growth. Recent evidence indicates that elevation of FAK activity in human carcinoma cells is associated with increased invasive potential. A central role in tumor formation and progression suggests that FAK is an attractive target for therapeutic intervention. Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397.

ALT Names :

Focal adhesion kinase 1;FADK 1;Protein-tyrosine kinase 2;pp125FAK

Immunogen :

KLH-conjugated linear peptide corresponding to human FAK phosphorylated at Tyr397.

Specificity :

This antibody recognizes FAK phosphorylated at Tyr397.

Package Size :

100 µL

Uses :

Western Blotting;Cell Function Assay

Storage :

Stable for 1 year at 2-8°C from date of receipt