KEAP1 Antibody | EMD Millipore ABS97 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

KEAP1 Antibody

catalog :

ABS97

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 1

Reference
Han X, Yao W, Liu Z, Li H, Zhang Z, Hei Z, et al. Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner. Oxid Med Cell Longev. 2016;2016:9303606 pubmed publisher

product information

Catalog Number :

ABS97

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-KEAP1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q14145

Host Name :

Rabbit

Antigen :

KEAP1

Conjugate :

Affinity Purified

Product Description :

Anti-KEAP1 Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

Anti-oxidant defense is known to be regulated by various mechanisms including the usage of nuclear factor erythroid 2-related factor 2 (Nrf2). Under normal physiological conditions, Nrf2 is bound to Kelch-like ECH-associated protein 1 (Keap1), a cytoplasmic repressor. Keap1 also acts as a substrate adaptor for Cullin3-dependent ubiquitin ligase and also targets Nrf2 for degradation by proteosomes. The substrate adaptor function of Keap1 is inactivated during physiological stress. In this respective condition, a range of oxidative and electrophilic stimuli such as ROS, diethyl malonate, and certain disease processes, resulting from Nrf2 accumulation, enters the nucleus and thereby activates the expression of select anti-oxidant genes. Such genes promote the detoxification of ROS and other harmful molecules, which contribute to the carcinogenesis.

ALT Names :

Cytosolic inhibitor of Nrf2;Kelch-like protein 19;INrf2

Immunogen :

KLH-conjugated linear peptide corresponding to the Kelch 3 region of human KEAP1.

Specificity :

This antibody recognizes the Kelch 3 region of KEAP1.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt