VEGF Antibody | EMD Millipore ABS82 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

VEGF Antibody

catalog :

ABS82

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 5

Reference
HWANG C, Marini S, Huber A, Stepien D, Sorkin M, Loder S, et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7:36 pubmed publisher
Elshaer S, El Remessy A. Deletion of p75NTR prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model. Sci Rep. 2018;8:12490 pubmed publisher
Fu C, Tyagi R, Chin A, Rojas T, Li R, Guha P, et al. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation. Circ Res. 2018;122:457-472 pubmed publisher
Elshaer S, Mohamed I, Coucha M, Altantawi S, Eldahshan W, Bartasi M, et al. Deletion of TXNIP Mitigates High-Fat Diet-Impaired Angiogenesis and Prevents Inflammation in a Mouse Model of Critical Limb Ischemia. Antioxidants (Basel). 2017;6: pubmed publisher
Jayaraman S, Doucet M, Kominsky S. Down-regulation of CITED2 attenuates breast tumor growth, vessel formation and TGF-β-induced expression of VEGFA. Oncotarget. 2017;8:6169-6178 pubmed publisher

product information

Catalog Number :

ABS82

Subcategory :

Cell Signaling

Product Name :

Anti-VEGF Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P15692

Host Name :

Rabbit

Antigen :

VEGF

Conjugate :

Affinity Purified

Product Description :

Anti-VEGF Antibody

Cross Reactivity :

Human;Mouse;Rat;Primate

Background :

VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines. VEGF induces angiogenesis as well as permeabilization of blood vessels, and plays a central role in the regulation of vasculogenesis. VEGF expression correlates to the degree of tumor vascularization and with increased metastatic risk. Additionally, VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis. Consequently, inhibition of VEGF signaling abrogates the development of a wide variety of tumors.

ALT Names :

vascular endothelial growth factor A;vascular endothelial growth factor;Vascular permeability factor;vascular endothelial growth factor isoform VEGF

Immunogen :

KLH-conjugated linear peptide corresponding to human VEGF at the N-terminus.

Specificity :

This antibody recognizes VEGF at the N-terminus.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt