AS160 Antibody | EMD Millipore ABS54 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

AS160 Antibody

catalog :

ABS54

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, bovine, chimpanzee

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:100; fig 5c western blot; mouse; 1:200; loading ...; fig 5a	Lisewski U, Koehncke C, Wilck N, Buschmeyer B, Pieske B, Roepke T. Increased aldosterone-dependent Kv1.5 recycling predisposes to pacing-induced atrial fibrillation in Kcne3-/- mice. FASEB J. 2016;30:2476-89 pubmed publisher
	Arias E, Zheng X, Agrawal S, Cartee G. Whole body glucoregulation and tissue-specific glucose uptake in a novel Akt substrate of 160 kDa knockout rat model. PLoS ONE. 2019;14:e0216236 pubmed publisher
	Hatakeyama H, Kanzaki M. Heterotypic endosomal fusion as an initial trigger for insulin-induced glucose transporter 4 (GLUT4) translocation in skeletal muscle. J Physiol. 2017;595:5603-5621 pubmed publisher
	Rogers R, Morris E, Wheatley J, Archer A, McCoin C, White K, et al. Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease. Diabetes. 2016;65:3341-3351 pubmed
	Sharma P, Arias E, Cartee G. Protein Phosphatase 1-? Regulates AS160 Ser588 and Thr642 Dephosphorylation in Skeletal Muscle. Diabetes. 2016;65:2606-17 pubmed publisher

product information

Catalog Number :

ABS54

Subcategory :

Cell Signaling

Product Name :

Anti-AS160 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8BYJ6

Host Name :

Rabbit

Antigen :

AS160

Conjugate :

Affinity Purified

Product Description :

Anti-AS160 Antibody

Cross Reactivity :

Mouse;Human;Canine;Rat

Background :

AS160 (Akt Substrate of 160 kDa, Akt1S1), Rab GAP (GTPase activating protein), is phosphorylated on multiple sites by Akt in response to insulin in adipocytes and contraction in muscles. AS160 is the long sought after link between the upstream insulin signaling through insulin/PI3K/Akt and GLUT4 vessicle translocation to the cell membrane. It has 6 Akt phosphorylation consensus sequences that are believed to become phosphorylated upon insulin stimulation. This phosphorylation is required for translocation of GLUT4-containing vesicles to the cell membrane1. A mutation of two or more of these phosphorylation sites results in a dramatic decrease in AS160 activity and insulin-stimulated GLUT4 redistribution at the cell membrane2. AS160 has also shown to be important for GLUT4 expcytosis2.

ALT Names :

Acrg embryonic lethality minimal region ortholog;Akt substrate of 160 kDa;TBC (Tre-2, BUB2, CDC16) domain-containing protein;TBC1 domain family, member

Immunogen :

KLH-conjugated linear peptide corresponding to the C-terminus of mouse AS160.

Specificity :

This antibody recognizes AS160 at the C-terminus.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt