Arginase-1 Antibody | EMD Millipore ABS535 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Arginase-1 Antibody

catalog :

ABS535

quantity :

100 μg

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 2

Reference
Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, et al. Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. PLoS Pathog. 2018;14:e1006955 pubmed publisher
Bichell T, Wegrzynowicz M, Tipps K, Bradley E, Uhouse M, Bryan M, et al. Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1596-1604 pubmed publisher

product information

Catalog Number :

ABS535

Subcategory :

Cell Signaling

Product Name :

Anti-Arginase-1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P07824

Host Name :

Chicken

Antigen :

ARG1

Conjugate :

Purified

Purification Method :

IgY purified from Yolk

Isotype :

IgY

Product Description :

Anti-Arginase-1 Antibody

Cross Reactivity :

Mouse, Rat, Guinea Pig, Human

Background :

Arginase-1, the protein encoded by the ARG1 gene, is the enzyme that catalyzes the breakdown of L-arginine into ornithine and urea. ARG1 is a key player in the Urea cycle. There are two distinct isoforms of Arginase, Arginase I and Arginase II. Arginase I (also called the liver type arginase or Type 1 arginase) is a highly expressed cytosolic enzyme in the liver and other tissues, including the brain. Arginase II or kidney-type arginase is also widely expressed at low levels in many tissues but localized to the mitochondria primarily. Interestingly, Arginase 1 has neuroprotective properties. Arginase I is essential for protecting motor neurons from nitric oxide dependent apoptosis that can be induced upon cellular stress or trophic factor removal. By suppressing nitric oxide production, Arginase prevents the formation of peroxynitrite and its subsequent cellular toxicity. Furthermore, Arginase 1 appears to play critical roles throughout the CNS for survival and regeneration of neurons and axons. In cancer, Arginase 1, already a useful marker for hepatocytes is also an excellent marker for hepatocellular cancers.

ALT Names :

Type 1 Arginase ARG1

Immunogen :

Full-length recombinant protein corresponding to Rat Arginase-1.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt