PI3 Kinase Antibody, p85 | EMD Millipore ABS234 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PI3 Kinase Antibody, p85

catalog :

ABS234

quantity :

200 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; mouse; loading ...; fig 6a western blot; mouse; loading ...; fig 6a	Roy N, MacKay J, Robertson T, Hammer D, Burkhardt J. Crk adaptor proteins mediate actin-dependent T cell migration and mechanosensing induced by the integrin LFA-1. Sci Signal. 2018;11: pubmed publisher
	Leblanc S, Wu Q, Lamba P, Sif S, Imbalzano A. Promoter-enhancer looping at the PPARÎ³2 locus during adipogenic differentiation requires the Prmt5 methyltransferase. Nucleic Acids Res. 2016;44:5133-47 pubmed publisher

product information

Catalog Number :

ABS234

Subcategory :

Cell Signaling

Product Name :

Anti-PI3 Kinase Antibody, p85

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q63787

Host Name :

Rabbit

Antigen :

PI3 Kinase

Conjugate :

Affinity Purified

Product Description :

Anti-PI3 Kinase Antibody, p85

Cross Reactivity :

Human;Rat

Background :

Phosphatidylinositol 3-Kinase (PI3 Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β,γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibited by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.

ALT Names :

Phosphatidylinositol 3-kinase regulatory subunit alpha;PI3-kinase regulatory subunit alpha;PI3K regulatory subunit alpha;PtdIns-3-kinase regulatory subunit alpha;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;PI3-kinase subunit p85-alpha;PtdIns-3-kinase regulatory subunit p85-alpha

Immunogen :

GST-tagged recombinant protein corresponding to rat PI3 Kinase, p85.

Package Size :

200 µL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt