PI3 Kinase p85 Antibody, N-SH2 domain | EMD Millipore ABS233 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PI3 Kinase p85 Antibody, N-SH2 domain

catalog :

ABS233

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 4c	Thauland T, Pellerin L, Ohgami R, Bacchetta R, Butte M. Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome. Front Immunol. 2019;10:753 pubmed publisher
immunoprecipitation; mouse; fig 6 western blot; mouse; fig 5	Winnay J, Solheim M, Dirice E, Sakaguchi M, Noh H, Kang H, et al. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016;126:1401-12 pubmed publisher
	Martins V, Tahvilian S, Kang J, Svensson K, Hetrick B, Chick W, et al. Calorie Restriction-Induced Increase in Skeletal Muscle Insulin Sensitivity Is Not Prevented by Overexpression of the p55α Subunit of Phosphoinositide 3-Kinase. Front Physiol. 2018;9:789 pubmed publisher
	Padilla Benavides T, Nasipak B, Paskavitz A, Haokip D, Schnabl J, Nickerson J, et al. Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition. J Biol Chem. 2017;292:18592-18607 pubmed publisher
	Iqbal A, Barrett T, Taylor L, McNeill E, Manmadhan A, Recio C, et al. Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo. elife. 2016;5: pubmed publisher

product information

Catalog Number :

ABS233

Subcategory :

Cell Signaling

Product Name :

Anti-PI3 Kinase p85 Antibody, N-SH2 domain

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q63787

Host Name :

Rabbit

Antigen :

PI3 Kinase p85

Conjugate :

Affinity Purified

Product Description :

Anti-PI3 Kinase p85 Antibody, N-SH2 domain

Cross Reactivity :

Human;Rat

Background :

Phosphatidylinositol 3-Kinase (PI3 Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β,γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibited by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.

ALT Names :

Phosphatidylinositol 3-kinase regulatory subunit alpha;PI3-kinase regulatory subunit alpha;PI3K regulatory subunit alpha;PtdIns-3-kinase regulatory subunit alpha;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;PI3-kinase subunit p85-alpha;PtdIns-3-kinase regulatory subunit p85-alpha

Immunogen :

GST-tagged recombinant protein corresponding to the N-SH2 domain of rat PI3 Kinase p85.

Specificity :

This antibody recognizes the N-SH2 domain of PI3 Kinase p85

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt