HMG-CoA reductase Antibody | EMD Millipore ABS229 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

HMG-CoA reductase Antibody

catalog :

ABS229

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

citations: 1

Reference
Kong Y, Cheng L, Mao F, Zhang Z, Zhang Y, Farah E, et al. Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC). J Biol Chem. 2018;293:14328-14341 pubmed publisher

product information

Catalog Number :

ABS229

Subcategory :

Cell Signaling

Product Name :

Anti-HMG-CoA reductase Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P04035

Host Name :

Rabbit

Antigen :

HMG-CoA reductase

Conjugate :

Affinity Purified

Product Description :

Anti-HMG-CoA reductase Antibody

Cross Reactivity :

Human

Background :

The 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) enzyme is a ubiquitously expressed glycoprotein that is bound to the membrane of the endoplasmic reticulum (ER), but also projects an active C-terminal catalytic tail into the cytoplasm. It is the rate-limiting enzyme in the mevalonate pathway as it catalyzes the conversion of HMG CoA to mevalonate, which is a critical precursor protein in the synthesis of sterols such as cholesterols. In mammalian cells, HMG-CoA reductase is regulated by multiple mechanisms. It is downregulated by high levels of exogenous cholesterol bound to the low density lipoprotein. It is also regulated by sterol and nonsterol metabolites of mevalonate which may exert inhibitory effects at the transcriptional level. Previous studies have suggested that sterols may inhibit the sterol regulatory element-binding proteins (SREBPs) which function as transcription factors that enhance the expression of genes required for sterol biosynthesis. The end-stage degradation process may be mediated by the ubiquitin degradation system. The inhibition of HMG-CoA reductase has been widely studied for the treatment of cholesterol-related conditions.

ALT Names :

3-hydroxy-3-methylglutaryl-coenzyme A reductase;HMG-CoA reductase

Immunogen :

KLH-conjugated linear peptide corresponding to the linker domain of human HMG CoA reductase.

Specificity :

This antibody recognizes HMG CoA reductase at the linker domain.

Package Size :

100 μg

Uses :

Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt