DEPTOR Antibody | EMD Millipore ABS222 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DEPTOR Antibody

catalog :

ABS222

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs

application :

western blot

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 3	Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
western blot; mouse; loading ...; fig s6f	Tsai S, Rodriguez A, Dastidar S, Del Greco E, Carr K, Sitzmann J, et al. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016;16:1903-14 pubmed publisher

product information

Catalog Number :

ABS222

Subcategory :

Metabolism

Product Name :

Anti-DEPTOR Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8TB45

Host Name :

Rabbit

Antigen :

DEPTOR

Conjugate :

Affinity Purified

Product Description :

Anti-DEPTOR Antibody

Cross Reactivity :

Human

Background :

DEPTOR (DEPDC6, DEP domain-containing protein 6) was recently identified as a novel mTOR-interacting protein whose over-expression in certain cell types represents a new mechanism for activating PI3K/Akt signaling and promoting cell survival. DEPTOR negatively regulates mTORC1 and mTORC2. It has been shown that loss of DEPTOR activates various targets that include p70S6K1, Akt, and SGK1, that leads to cell growth and survival. Little was known about DEPDC6 prior to the discovery of its interactions with mTOR, at which time it was given the new name of DEPTOR (Peterson, T.R., et al. (2009). Cell. 137(5):873-876).

ALT Names :

DEP domain-containing mTOR-interacting protein;DEP domain-containing protein 6

Immunogen :

KLH-conjugated linear peptide corresponding to the DEP domain-containing mTOR-interacting protein of human DEPTOR.

Specificity :

This antibody recognizes the DEP domain that contains mTOR-interacting protein DEPTOR.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt