phospho-PDHE1-A type I (Ser293) Antibody | EMD Millipore ABS204 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-PDHE1-A type I (Ser293) Antibody

catalog :

ABS204

quantity :

50 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, bovine, zebrafish

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 2c	Krycer J, Elkington S, Díaz Vegas A, Cooke K, Burchfield J, Fisher Wellman K, et al. Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes. J Biol Chem. 2020;295:99-110 pubmed publisher
western blot; mouse; loading ...; fig 2a	Lacroix M, Rodier G, Kirsh O, Houles T, Delpech H, Seyran B, et al. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A. 2016;113:10998-1003 pubmed publisher
	Willis I, Moir R, Hernandez N. Metabolic programming a lean phenotype by deregulation of RNA polymerase III. Proc Natl Acad Sci U S A. 2018;115:12182-12187 pubmed publisher
	Chen J, Guccini I, Di Mitri D, Brina D, Revandkar A, Sarti M, et al. Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer. Nat Genet. 2018;50:219-228 pubmed publisher
	Bas Orth C, Tan Y, Lau D, Bading H. Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect. J Biol Chem. 2017;292:5183-5194 pubmed publisher
	Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork Geleta A, Blecha J, Endaya B, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer. Antioxid Redox Signal. 2017;26:84-103 pubmed publisher
	Meiser J, KrÃ¤mer L, Sapcariu S, Battello N, Ghelfi J, d Herouël A, et al. Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression. J Biol Chem. 2016;291:3932-46 pubmed publisher

product information

Catalog Number :

ABS204

Subcategory :

Metabolism

Product Name :

Anti-phospho-PDHE1-A type I (Ser293) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P08559

Host Name :

Rabbit

Antigen :

phospho-PDHE1-A type I (Ser293)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-PDHE1-A type I (Ser293) Antibody

Cross Reactivity :

Human;Rat;Mouse;Bovine;Primate

Background :

In many organisms, the pyruvate dehydrogenase (PDH) complex catalyzes the overall, irreversible conversion of pyruvate to acetyl-CoA and CO2 in the aerobic pathway. This complex also serves as a key regulator for cardiac substrate selection. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1 or PDHE1-A type I), dihydrolipoamide acetyltransferase (E2), and lipoamide dehydrogenase (E3). PDH is regulated by both pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation and feedback inhibition.

ALT Names :

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Immunogen :

KLH-conjugated linear peptide corresponding to human PDHE1-A type I phosphorylated at Ser293.

Specificity :

This antibody recognizes PDHE1-A type I phosphorylated at Ser293.

Package Size :

50 µL

Uses :

Western Blotting;Immunocytochemistry;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt