NeuN purified Antibody | EMD Millipore ABN90P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NeuN purified Antibody

catalog :

ABN90P

quantity :

100 µL

clonality :

polyclonal

host :

guinea-pigs

conjugate :

nonconjugated

reactivity :

African green monkey, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry knockout validation

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:400; loading ...; fig 1a	BARTSCH V, Niehaus J, Taylor Blake B, Zylka M. Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice. PLoS ONE. 2019;14:e0217819 pubmed publisher
immunohistochemistry; African green monkey; 1:1000; loading ...; fig 4b	Chareyron L, Amaral D, Lavenex P. Selective lesion of the hippocampus increases the differentiation of immature neurons in the monkey amygdala. Proc Natl Acad Sci U S A. 2016;113:14420-14425 pubmed
	Murray H, Dieriks B, Swanson M, Anekal P, Turner C, Faull R, et al. The unfolded protein response is activated in the olfactory system in Alzheimer's disease. Acta Neuropathol Commun. 2020;8:109 pubmed publisher
	Lennox A, Hoye M, Jiang R, Johnson Kerner B, Suit L, Venkataramanan S, et al. Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development. Neuron. 2020;106:404-420.e8 pubmed publisher
	McCoy E, Taylor Blake B, Aita M, Simon J, Philpot B, Zylka M. Enhanced Nociception in Angelman Syndrome Model Mice. J Neurosci. 2017;37:10230-10239 pubmed publisher
	Avila D, Myers S, Zhang J, Kharebava G, McClain C, Kim H, et al. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Neuropharmacology. 2017;125:376-385 pubmed publisher
	Battefeld A, Klooster J, Kole M. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Nat Commun. 2016;7:11298 pubmed publisher
	Pearson B, Simon J, McCoy E, Salazar G, Fragola G, Zylka M. Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nat Commun. 2016;7:11173 pubmed publisher

product information

Catalog Number :

ABN90P

Subcategory :

Neuroscience

Product Name :

Anti-NeuN purified Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Host Name :

Guinea Pig

Antigen :

NeuN purified

Conjugate :

Affinity Purified

Product Description :

Anti-NeuN purified Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

ABN90P is a Guinea Pig polyclonal version of the Anti-NeuN, clone A60 (MAB377), a highly characterized and cited mouse monoclonal antibody that specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are some examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found.

ALT Names :

NEUronal Nuclei;clone A60;NeuN

Immunogen :

GST-tagged recombinant protein corresponding to the N-terminus of mouse NeuN.

Specificity :

This antibody recognizes the N-terminus of NeuN.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt