NeuN (rabbit) Antibody, Alexa Fluor® 488 Conjugate | EMD Millipore ABN78A4 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NeuN (rabbit) Antibody, Alexa Fluor® 488 Conjugate

catalog :

ABN78A4

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

AF488

reactivity :

mouse

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:500; fig 1	Mitchell A, Javidfar B, Bicks L, Neve R, Garbett K, Lander S, et al. Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nat Commun. 2016;7:12743 pubmed publisher
	Ayhan F, Perez B, Shorrock H, Zu T, Bañez Coronel M, Reid T, et al. SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. EMBO J. 2018;37: pubmed publisher
	McGill B, Barve R, Maloney S, Strickland A, Rensing N, Wang P, et al. Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre-Expressing Neurons. J Neurosci. 2018;38:200-219 pubmed publisher
	Zhao M, Liang F, Xu H, Yan W, Zhang J. Methylene blue exerts a neuroprotective effect against traumatic brain injury by promoting autophagy and inhibiting microglial activation. Mol Med Rep. 2016;13:13-20 pubmed publisher

product information

Catalog Number :

ABN78A4

Subcategory :

Neuroscience

Product Name :

Anti-NeuN (rabbit) Antibody, Alexa Fluor® 488 Conjugate

Product Type :

Antibodies

Host Name :

Rabbit

Antigen :

NeuN (rabbit)

Conjugate :

AlexaFluor®488

Product Description :

Anti-NeuN (rabbit) Antibody, Alexa Fluor® 488 Conjugate

Cross Reactivity :

Mouse;Rat

Background :

ABN78 is a rabbit polyclonal version of the Anti-NeuN, clone A60 (MAB377), NeuN is a highly characterized and cited mouse monoclonal antibody that specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found.

ALT Names :

NEUronal Nuclei;Neuronal Nuclei

Immunogen :

GST-tagged recombinant protein corresponding to mouse NeuN.

Specificity :

This antibody recognizes NeuN at the N-terminus.

Package Size :

100 µL

Uses :

Immunocytochemistry;Immunohistochemistry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.