LXRbeta Antibody | EMD Millipore ABN65 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LXRbeta Antibody

catalog :

ABN65

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig 6d	Castella B, Kopecka J, Sciancalepore P, Mandili G, Foglietta M, Mitro N, et al. The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. Nat Commun. 2017;8:15663 pubmed publisher

product information

Catalog Number :

ABN65

Subcategory :

Neuroscience

Product Name :

Anti-LXRbeta Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P55055

Host Name :

Rabbit

Antigen :

LXRbeta

Conjugate :

Affinity Purified

Product Description :

Anti-LXRbeta Antibody

Cross Reactivity :

Human

Background :

LXRa and LXRb (NR1H3 and NR1H2, respectively) are ligand-activated nuclear receptors that mediate cholesterol homeostasis. Once activated, LXRs upregulate the transcription of genes involved in cholesterol transport such as those encoding ATP-binding cassette (ABC) transporters, including ATP-binding cassette protein A (ABCA)1 and apolipoprotein E (Apo E), in various brain diseases. ABCA1 is known to carry and deliver cholesterol through receptor-mediated endocytosis, while in Alzheimer’s brain, both ABCA1 and Apo E are shown to influence amyloid-beta transport and clearance. It is also shown that LXR ligands inhibit STAT1 binding to related gene promoters and the downstream expression of IRF1, TNFa, and IL-6. One study reports that differential SUMOlyation of LXRa and LXRb positively transrepresses STAT1 inflammatory signaling in IFN-g-stimulated rat brain astrocytes and that transient tranfection of specific individual siRNAs against LXRb and LXRa blocks LXR-induced suppression of IRF1 and TNFa expression.

ALT Names :

Oxysterols receptor LXR-beta;liver X receptor beta;Nnclear receptor NER;Nuclear receptor subfamily 1 group H member 2;Ubiquitously-expressed nuclear receptor

Immunogen :

KLH-conjugated linear peptide corresponding to the N-terminus of human LXRbeta.

Specificity :

This antibody recognizes the N-terminus of LXRbeta.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt