Tau (T22), oligomeric | EMD Millipore ABN454 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tau (T22), oligomeric

catalog :

ABN454

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 1d	Merezhko M, Brunello C, Yan X, Vihinen H, Jokitalo E, Uronen R, et al. Secretion of Tau via an Unconventional Non-vesicular Mechanism. Cell Rep. 2018;25:2027-2035.e4 pubmed publisher
	Farmer K, Ghag G, Puangmalai N, Montalbano M, Bhatt N, Kayed R. P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease. Acta Neuropathol Commun. 2020;8:132 pubmed publisher
	Wang Y, Hall R, Lee M, Kamgar Parsi A, Bi X, Baudry M. The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Sci Rep. 2017;7:11771 pubmed publisher
	Castillo Carranza D, Nilson A, Van Skike C, Jahrling J, Patel K, Garach P, et al. Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies. Aging Dis. 2017;8:257-266 pubmed publisher
	Acosta S, Tajiri N, Sanberg P, Kaneko Y, Borlongan C. Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury. J Cell Physiol. 2017;232:665-677 pubmed publisher

product information

Catalog Number :

ABN454

Subcategory :

Neuroscience

Product Name :

Anti-Tau (T22), oligomeric

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P10636

Host Name :

Rabbit

Antigen :

MAPT

Conjugate :

Serum

Purification Method :

Unpurified

Product Description :

Anti-Tau (T22), oligomeric

Cross Reactivity :

Human, Mouse, Rat

Background :

In Alzheimer's disease (AD) pathology, accumulation of the microtubule-associated protein tau takes place primarily in the neurons. Tau accumulates in both the somatodendritic and axonal domains of neurons. Tau also accumulates in the soma as neurofibrillary tangles (NFTs). Cell death and synaptic lesions occur independently of NFT formation, and research indicates that NFT formation alone is insufficient for neurodegeneration. This suggests that soluble tau aggregates may be the most toxic and pathologically significant tau species. Tau oligomers are neurotoxic when applied extracellularly to cultured neuronal cells tau oligomers (but not fibrils) induce neurodegeneration and synaptic and mitochondrial dysfunction in vivo. Moreover using a new Tau oligomer specific antibody, Tau (T22), researchers were able to use tau oligomers as a reliable biomarker to differentiate patients with AD from age-matched controls. Tau (T22) should further allow researchers to begin to analyze the relation between tau aggregation, amyloid, and disease progression.

ALT Names :

Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, Oligomeric Tau

Immunogen :

Tau oligomers corresponding to human oligomeric Tau (T22).

Package Size :

100 µL

Uses :

Western Blotting, Dot Blot, Immunohistochemistry, Immunocytochemistry, Neutralizing, Immunoprecipitation

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.