GluR1 Antibody | EMD Millipore ABN241 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GluR1 Antibody

catalog :

ABN241

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000; fig 6a	McQuail J, Beas B, Kelly K, Simpson K, Frazier C, Setlow B, et al. NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline. J Neurosci. 2016;36:12537-12548 pubmed
	Wu T, Donohoe M. Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization. J Biomed Sci. 2019;26:79 pubmed publisher
	Purkey A, Woolfrey K, Crosby K, Stich D, Chick W, Aoto J, et al. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018;25:974-987.e4 pubmed publisher
	Kim J, Lee S, Kang S, Jeon T, Kang M, Lee T, et al. Regulator of G-Protein Signaling 4 (RGS4) Controls Morphine Reward by Glutamate Receptor Activation in the Nucleus Accumbens of Mouse Brain. Mol Cells. 2018;41:454-464 pubmed publisher
	Sanderson J, Scott J, Dell Acqua M. Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca2+-Permeable AMPA Receptors. J Neurosci. 2018;38:2863-2876 pubmed publisher
	Sellers K, Elliott C, Jackson J, Ghosh A, Ribe E, Rojo A, et al. Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimers Dement. 2018;14:306-317 pubmed publisher

product information

Catalog Number :

ABN241

Subcategory :

Neuroscience

Product Name :

Anti-GluR1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P19490

Host Name :

Rabbit

Antigen :

GluR1

Conjugate :

Affinity Purified

Product Description :

Anti-GluR1 Antibody

Cross Reactivity :

Mouse;Rat;Human

Background :

Glutamate receptors (GluRs) are a diverse group responsible for mediating most of the excitatory synaptic transmission in the CNS of vertebrates. They can be categorized as ionotropic or metabotropic and subcategorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. The critical residue controlling calcium permeability is in the pore loop region. In GluR1, GluR3, and GluR4, this position is occupied by a Gln residue. The insertion or removal of GluR1/GluR4 oligomeric channels from postsynaptic membranes appears to be LTP/LTD activity dependent while GluR2/GluR3 oligomers are continuously cycling.

ALT Names :

Glutamate receptor 1;GluR-1;AMPA-selective glutamate receptor 1;GluR-A;GluR-K1;Glutamate receptor ionotropic, AMPA 1;GluA1

Immunogen :

KLH-conjugated linear peptide corresponding to the extracellular domain of rat GluR1.

Specificity :

This antibody recognizes the extracellular domain of GluR1.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt