Amyloid, β 1-40, aβ Antibody | EMD Millipore ABN240 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Amyloid, β 1-40, aβ Antibody

catalog :

ABN240

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse; loading ...; fig 1a	Qin X, Wang Y, Paudel H. Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of ?-Secretase 1 (BACE-1) in the Brain. J Biol Chem. 2016;291:22276-22287 pubmed

product information

Catalog Number :

ABN240

Subcategory :

Neuroscience

Product Name :

Anti-Amyloid, β 1-40, aβ Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P05067

Host Name :

Rabbit

Antigen :

Amyloid

Conjugate :

Affinity Purified

Product Description :

Anti-Amyloid, β 1-40, aβ Antibody

Cross Reactivity :

Human

Background :

Amyloid β 1-40 is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions including axonal transport, cell adhesion, and transcription, the amyloid β 1-40 peptide has been studied mostly for its role in neurotoxicity, particularly in the context of Alzheimer’s disease. Previous studies have reported that expression of amyloid β 1-40 increases in Alzheimer’s disease and correlate with the occurrence of aberrant synaptic structure and cognitive dysfunction. These detrimental effects on neural function may be related to aggregation of this peptide (formation of neurite plaques), as neurite plaques been shown to disrupt multiple neurotransmitter systems, and synaptic events such as long-term potentiation.

ALT Names :

Amyloid beta A4 protein;ABPP;APPI;APP;Alzheimer disease amyloid protein;Cerebral vascular amyloid peptide;CVAP;PreA4;Protease nexin-II;PN-II;1.N-APP2.Soluble APP-alpha;S-APP-alpha3.Soluble APP-beta;S-APP-beta4.C995.Beta-amyloid protein 42;Beta-APP426.Beta-amyloid protein 40;Beta-APP407.C838.P3(42)9.P3(40)10.C8011.Gamma-secretase C-terminal fragment 59;Amyloid intracellular domain 59;AICD-59;AID(59);Gamma-CTF(59)12.Gamma-secretase C-terminal fragment 57;Amyloid intracellular domain 57;AICD-57;AID(57);Gamma-CTF(57)13.Gamma-secretase C-terminal fragment 50;Amyloid intracellular domain 50;AICD-50;AID(50);Gamma-CTF(50)14.C31

Immunogen :

KLH-conjugated linear peptide corresponding to the P3(40) peptide of human Amyloid, B 1-40.

Specificity :

This antibody recognizes the P3(40) peptide of Amyloid, β 1-40.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry (Paraffin);ELISA

Storage :

Stable for 1 year at 2-8°C from date of receipt