PABPC1/C3 Antibody | EMD Millipore ABE40 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PABPC1/C3 Antibody

catalog :

ABE40

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, chicken, bovine

application :

western blot, immunocytochemistry

citations: 1

Reference
Barragán Iglesias P, Lou T, Bhat V, Megat S, Burton M, Price T, et al. Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice. Nat Commun. 2018;9:10 pubmed publisher

product information

Catalog Number :

ABE40

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-PABPC1/C3 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P11940

Host Name :

Rabbit

Antigen :

PABPC1/C3

Conjugate :

Affinity Purified

Product Description :

Anti-PABPC1/C3 Antibody

Cross Reactivity :

Human;Mouse;Rat;Bovine;Canine;Xenopus;Chicken

Background :

Poly(A)-binding proteins, cytoplasmic 1 (PABPC1), and cytoplasmic 3 (PABPC3) are RNA-binding proteins with important roles in post-translational control and metabolism of mRNA. Although both proteins bind to the poly(A) tail of mRNA, PABPC3 binds with a lower affinity than PABPC1. Studies have associated these proteins with tumorigenesis. Decreased expression of PABPC1 in esophageal cancer seems to associate with tumor development and poor prognosis after surgery. PABPC1 can shuttle through the nuclear membrane and is thought to associate with newly synthesized poly(A) transcripts. PABPC1 has also been linked to microRNA mediated silencing when in contact with GW182. PABPC3 is thought to be specific to human testis and controls RNA stability.

ALT Names :

Polyadenylate-binding protein 1;PABP-1;Poly(A)-binding protein 1

Immunogen :

KLH-conjugated linear peptide corresponding to human PABPC1/C3. The immunogen sequence used is 100% identical to both PABPC1 and PABPC3.

Package Size :

100 μg

Uses :

Immunocytochemistry;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt