RNF168 Antibody | EMD Millipore ABE367 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RNF168 Antibody

catalog :

ABE367

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; loading ...; fig 1h	Huo D, Chen H, Cheng Y, Song X, Zhang K, Li M, et al. JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity. Cell Death Differ. 2019;: pubmed publisher
immunocytochemistry; human; 1:1000; loading ...; fig s3b western blot; human; 1:1000; loading ...; fig s3a	Bot C, Pfeiffer A, Giordano F, Manjeera D, Dantuma N, Ström L. Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. J Cell Sci. 2017;130:1134-1146 pubmed publisher
	Baranes Bachar K, Levy Barda A, Oehler J, Reid D, Soria Bretones I, Voss T, et al. The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. Mol Cell. 2018;69:866-878.e7 pubmed publisher
	Xie X, Hu H, Tong X, Li L, Liu X, Chen M, et al. The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. Nat Cell Biol. 2018;20:320-331 pubmed publisher
	Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, et al. Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Nat Cell Biol. 2017;19:1400-1411 pubmed publisher

product information

Catalog Number :

ABE367

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-RNF168 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8IYW5

Host Name :

Rabbit

Antigen :

RNF168

Conjugate :

Affinity Purified

Product Description :

Anti-RNF168 Antibody

Cross Reactivity :

Human

Background :

RNF168 is a ubiquitin ligand that binds to ubiquinated histone H2A and localizes to sites of DNA damage. RNF168-dependent chromatin modifications cause 53BP1 and BRCA1 to accumulated at the site. A mutation in RNF168 has been associated with RIDDLE syndrome, an immunodeficiency and radiosensitivity disorder. RNF168 is responsible for securing repair factors at sites of DNA damage. RNF168 has two MIU (motif interacting with ubiquitin) and one UMI (UIM- and MIU-related UBD) ubiquitin binding domains (UBDs) which are essential for proper localization of RNF168.

ALT Names :

E3 ubiquitin-protein ligase RNF168;RING finger protein 168

Immunogen :

Histidine-tagged recombinant protein corresponding to the C-terminus of human RNF168.

Specificity :

This antibody recognizes RNF168 at the C-terminus.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;Immunofluorescence

Storage :

Stable for 1 year at 2-8°C from date of receipt