Tristetraprolin Antibody | EMD Millipore ABE285 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tristetraprolin Antibody

catalog :

ABE285

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Reference
Haneklaus M, O Neil J, Clark A, Masters S, O Neill L. The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome. J Biol Chem. 2017;292:6869-6881 pubmed publisher
Liu X, Li X, Ma R, Xiong B, Sun S, Liu H, et al. Tristetraprolin functions in cytoskeletal organization during mouse oocyte maturation. Oncotarget. 2016;7:53330-53338 pubmed publisher

product information

Catalog Number :

ABE285

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Tristetraprolin Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P26651

Host Name :

Rabbit

Antigen :

Tristetraprolin

Conjugate :

Affinity Purified

Product Description :

Anti-Tristetraprolin Antibody

Cross Reactivity :

Human;Mouse

Background :

Tristetraprolin (TTP, Nup 475, TIS11, G0S24, or ZFP36) is a member of the CCCH tandem zinc finger protein family. It is a nuclear RNA-binding protein that functions as a trans-acting factor. It is involved in post-transcriptional regulation of cytokine genes, most notably Tumor Necrosis Factor alpha (TNF-α). Upon activation by lipopolysaccharides, TTP binds TNF-α mRNA at AU-rich domains in the 3'-untranslated Region (3'-UTR) and induces deadenylation, thereby destabilizing the mRNA and tagging it for degradation. To produce this effect, TTP recruits other trans-acting factors to its C-terminal domain and mRNA-decay enzymes to its N-terminal domain. TTP is deactivated by phosphorylation driven by mitogen-activated protein kinase-activated protein kinase 2 (MK2) and p53. Therefore, TTP/MK2 regulates the biosynthesis of TNF-α and mediates inflammatory responses involving TNF-α. Knockout of TTP in mice produces arthritis, alopecia, dermatitis, among a range of other phenotypes related to overexpression of TNF-α.

ALT Names :

Tristetraprolin;TTP;G0/G1 switch regulatory protein 24;Growth factor-inducible nuclear protein NUP475;Protein TIS11A;TIS11;Zinc finger protein 36 homolog;Zfp-36

Immunogen :

KLH-conjugated linear peptide corresponding to human Tristetraprolin.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;Immunoprecipitation;RNA Binding Protein Immunoprecipitation (RIP)

Storage :

Stable for 1 year at 2-8°C from date of receipt