acetyl-c-Myc (Lys323) Antibody | EMD Millipore ABE26 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl-c-Myc (Lys323) Antibody

catalog :

ABE26

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 2	Perumal D, Kuo P, Leshchenko V, Jiang Z, Divakar S, Cho H, et al. Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Cancer Res. 2016;76:1225-36 pubmed publisher

product information

Catalog Number :

ABE26

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-acetyl-c-Myc (Lys323) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P01106

Host Name :

Rabbit

Antigen :

acetyl-c-Myc (Lys323)

Conjugate :

Affinity Purified

Product Description :

Anti-acetyl-c-Myc (Lys323) Antibody

Cross Reactivity :

Human;Mouse

Background :

c-Myc (bHLHe39) is a transcription factor that regulates the expression of multiple genes involved in apoptosis, cell growth, differentiation, and proliferation. Active c-Myc is coupled to the MAX protein via c-Myc’s C-terminal helix-loop-helix leucine zipper (bHLHLZ) domain. The c-Myc-MAX heterodimer also interacts with a number of other transcription-related proteins including TRRAP, p107 and Miz-1, and c-Myc-MAX may indirectly regulate histone acetylases involved in chromatin remodeling. c-Myc is itself acetylated on lysine 323 by GCN5, and on lysine 148 and 157 by p300/CBP. The significance of c-Myc acetylation is still under investigation; however, previous studies have suggested that HAT-dependent acetylation of c-Myc may regulate its turnover and stability. c-Myc may play a role in various cancers such as Burkitt’s lymphoma.

ALT Names :

Myc proto-oncogene protein;Class E basic helix-loop-helix protein 39;HLHe39;Proto-oncogene c-Myc;Transcription factor p64;c-MYC

Immunogen :

KLH-conjugated linear peptide corresponding to human c-Myc acetylated at Lys323.

Specificity :

This antibody recognizes c-Myc acetylated at Lys323.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt