N-CoR Antibody | EMD Millipore ABE251 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

N-CoR Antibody

catalog :

ABE251

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

citations: 1

Reference
Luo Z, Qing X, Benda C, Huang Z, Zhang M, Huang Y, et al. Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming. Cell Regen (Lond). 2019;8:21-29 pubmed publisher

product information

Catalog Number :

ABE251

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-N-CoR Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q60974.

Host Name :

Rabbit

Antigen :

N-CoR

Conjugate :

Affinity Purified

Product Description :

Anti-N-CoR Antibody

Cross Reactivity :

Human;Mouse

Background :

In the absence of ligands, the corepressor N-CoR represses nuclear hormone receptor-mediated gene transcription. In the presence of ligands, these hormone receptors activate gene expression and play critical roles in development, growth, and homeostasis. N-Cor-mediated transcriptional repression is facilitated through the formation of histone deacetylase (HDACs) N-CoR complexes or by conjugation from small ubiquitin-like modifier 1 (SUMO-1). It is shown that the SANT1 domain of N-CoR serves as a binding region for SUMO-E2 conjugating enzyme Ubc9 and SUMO-E3 ligase Pias1, which is necessary for N-CoR-mediated repression of respective reporter genes. SUMOylation-deficient N-COR knockout mice display a signification reduction in the repression of gene transcription and result in defects involving the differentiation and development of neural cells into erythrocytes and thymocytes.

ALT Names :

Nuclear receptor corepressor 1;N-CoR;N-CoR1;Retinoid X receptor-interacting protein 13

Immunogen :

KLH-conjugated linear peptide corresponding to a region between amino acids 1510 and 1540 of the N-CoR protein.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt