MLL-C Antibody | EMD Millipore ABE240 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MLL-C Antibody

catalog :

ABE240

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, chromatin immunoprecipitation

citations: 1

Reference
Rahman S, Zorca C, Traboulsi T, Noutahi E, Krause M, Mader S, et al. Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription. Nucleic Acids Res. 2017;45:3017-3030 pubmed publisher

product information

Catalog Number :

ABE240

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-MLL-C Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q03164

Host Name :

Rabbit

Antigen :

MLL-C

Conjugate :

Affinity Purified

Product Description :

Anti-MLL-C Antibody

Cross Reactivity :

Human;Mouse

Background :

MLL is a histone methyltransferase and chromatin modifier that plays a role in hematopoiesis. This protein is implicated in HOX gene regulation in early embryogenesis and in the regulation of non-HOX genes p27 (Kip1) and p18 (lnk4C). It is part of a catalytic subunit of the MLL1/MLL complex, which mediates the acetylation of Lys-16 of histone H4 (H4K16ac) and the methylation of Lys-4 of histone H3 (H3K4me). It is reported that MLL interacts directly with the polymerase associated factor complex (PAFc) through sequences flanking the CxxC domain. Subsequently, PAFc interacts with RNA polymerase II and thereby stimulates posttranslational histone modifications. Taspase 1, catalyzes MLL into MLL-C and MLL-N, both of which reassociate and later reassemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Mutations in the MLL gene are linked to certain acute myeloid and lymphoid leukemias.

ALT Names :

Histone-lysine N-methyltransferase MLL, ALL-1;CXXC-type zinc finger protein 7;Lysine N-methyltransferase 2A;KMT2A; Trithorax-like protein;Zinc finger protein HRX;MLL cleavage product C180;C-terminal cleavage product of 180 kDa;p180

Immunogen :

GST-tagged recombinant protein corresponding to the expressed protein of human MLL-C.

Package Size :

100 µL

Uses :

Western Blotting;Immunocytochemistry;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at 2-8°C from date of receipt