MeCP2 Antibody | EMD Millipore ABE171 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MeCP2 Antibody

catalog :

ABE171

quantity :

100 μg

clonality :

polyclonal

host :

chicken

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 2

Reference
Philippe T, Vahid Ansari F, Donaldson Z, Le François B, Zahrai A, Turcotte Cardin V, et al. Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes. Sci Rep. 2018;8:5788 pubmed publisher
Bueno C, Tabares Seisdedos R, Moraleda J, Martinez S. Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands. PLoS ONE. 2016;11:e0153262 pubmed publisher

product information

Catalog Number :

ABE171

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-MeCP2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P51608

Host Name :

Chicken

Antigen :

MeCP2

Conjugate :

Affinity Purified

Isotype :

IgY

Product Description :

Anti-MeCP2 Antibody

Cross Reactivity :

Mouse;Rat;Human

Background :

MeCp2 (methyl-CpG-binding protein 2) binds methylated CpG sequences in double-stranded DNA resulting in the suppression of transcription. Although MeCp2 is not essential in stem cells, it is critical for embryonic development. This protein seems to be particularly important for mature nerve cells, where it is present in high levels. The MeCp2 protein is likely to be involved in turning off ("repressing" or "silencing") several other genes. Consistent with this role, mutations of MeCp2 are linked to Rett syndrome (RTT), a progressive neurological disorder that is one of the most common causes of mental retardation in females.

ALT Names :

methyl CpG binding protein 2 (Rett syndrome);mental retardation, X-linked 16;MeCp-2 protein;mental retardation, X-linked 79;methyl-CpG-binding protein 2

Immunogen :

KLH-conjugated linear peptide corresponding to human MeCp2.

Package Size :

100 μg

Uses :

Western Blotting;Chromatin Immunoprecipitation (ChIP);Immunoprecipitation

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.