HRS (HGS) Antibody | EMD Millipore ABC35 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

HRS (HGS) Antibody

catalog :

ABC35

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, cow

application :

western blot

product information

Catalog Number :

ABC35

Subcategory :

Cell Signaling

Product Name :

Anti-HRS (HGS) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O14964

Host Name :

Rabbit

Antigen :

HRS (HGS)

Conjugate :

Affinity Purified

Product Description :

Anti-HRS (HGS) Antibody

Cross Reactivity :

Human;Mouse

Background :

Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), otherwise known as HGS or Protein pp110, is a ubiquitously expressed zinc finger protein. HRS is heavily phosphorylated by receptor tyrosine kinases in response to signals from growth factors. It has been detected in vesicular structures and early endosomes and plays a crucial role in endocytosis and vesicle trafficking, which may underlie the downregulation of growth factor receptors such as the epidermal growth factor receptor (EGFR). In order to perform this function, HRS is ubiquitinated at its ubiquitin interacting motif (UIM). This allows interaction of HRS with similarly ubiquitinated vesicle-related proteins such as STAM1 and Eps15, as well as ubiquitinated receptors tagged for lysosomal degradation. Complexes of HRS and STAM1 are located in vesicular membranes and regulate the sorting of tagged receptors to the lysosomes.

ALT Names :

Hepatocyte growth factor-regulated tyrosine kinase substrate;Hrs;Protein pp110;HRS

Immunogen :

KLH-conjugated linear peptide corresponding to the interaction with SNX1 region of human HRS.

Specificity :

This antibody recognizes HRS at the interaction with SNX1 region.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt