ACVR1 Antibody | EMD Millipore ABC330 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ACVR1 Antibody

catalog :

ABC330

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunocytochemistry

citations: 1

Reference
Lisse T, Rieger S. IKKα regulates human keratinocyte migration through surveillance of the redox environment. J Cell Sci. 2017;130:975-988 pubmed publisher

product information

Catalog Number :

ABC330

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-ACVR1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q04771

Host Name :

Rabbit

Antigen :

ACVR1

Conjugate :

Affinity Purified

Product Description :

Anti-ACVR1 Antibody

Cross Reactivity :

Human

Background :

Activin receptor type-1 (ACVR1) is a member of the protein kinase superfamily, and more specifically to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily. Activins are growth and differentiation factors that belong to the transforming growth factor-beta (TGF-beta) superfamily. ACVR1 plays a role in ligand binding and forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. The process of forming this receptor complex involves the phosphorylation of Type II receptors; the activation of Type I receptors; the autophosphorylation of Type I receptors, which then bind and activate SMAD transcriptional regulators. ACVR1 is expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Furthermore, ACVR1 is shown to interact with FKBP1A and FCHO1. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) - a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Additionally, ACVR1 may play a role in the left-right pattern formation during embryogenesis.

ALT Names :

ACVR1;Activin A receptor type IA;Activin receptor-like kinase 2;Activin receptor type 1A precursor;Serine/threonine-protein kinase receptor R1;SKR1;TGF-B superfamily receptor type I;TSR-I;ACTR-IA;ACVRLK2;ALK2;ALK-2

Immunogen :

KLH-conjugated linear peptide corresponding to human ACVR1.

Specificity :

This antibody recognizes the N-terminus of ACVR1.

Package Size :

100 μg

Uses :

Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt