MCM7 Antibody | EMD Millipore ABC157 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MCM7 Antibody

catalog :

ABC157

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat, chimpanzee, Rhesus monkey

application :

western blot

product information

Catalog Number :

ABC157

Subcategory :

Cell Structure

Product Name :

Anti-MCM7 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P33993

Host Name :

Rabbit

Antigen :

MCM7

Conjugate :

Purified

Product Description :

Anti-MCM7 Antibody

Cross Reactivity :

Human;Rat;Rhesus Macaque;Chimpanzee

Background :

MCM7 is a highly conserved mini-chromosome maintenance protein (MCM) that is involved in the initiation of eukaryotic genome replication. It forms a hexameric complex with MCM4 and MCM6 (two subunits of MCM7, two subunits of MCM4 and two subunits of MCM7) and this complex regulates the helicase activity of the pre-replication complex. This complex is also involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. MCM7 is reported to bind to DNA in metaphase II in oocytes and remains associated with the DNA until the S-phase. Two isoforms of MCM7 have been reported, 61 kDa and 90 kDa. In neuroblastoma tumors MCM7 expression is shown to correlates with MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived) amplification where in MCM7 is rapidly up-regulated by Inducible MYCN Expression. MYCN protein is shown to bind specifically to the MCM7 promoter region, which possesses an E-box binding site for the Myc oncoproteins.

ALT Names :

DNA replication licensing factor MCM7;CDC47 homolog;P1.1-MCM3

Immunogen :

KLH-conjugated linear peptide corresponding to the N-terminus of human MCM7.

Specificity :

This antibody recognizes the N-terminus of MCM7

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt