phospho-Rb (Ser807/Ser811) Antibody | EMD Millipore ABC132 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Rb (Ser807/Ser811) Antibody

catalog :

ABC132

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, chicken

application :

western blot

product information

Catalog Number :

ABC132

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-phospho-Rb (Ser807/Ser811) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P06400

Host Name :

Rabbit

Antigen :

phospho-Rb (Ser807/Ser811)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-Rb (Ser807/Ser811) Antibody

Cross Reactivity :

Human;Mouse

Background :

The retinoblastoma (Rb) gene product (also known as p105, p110 or pRb) is a tumor suppressor protein that is missing or mutated in a variety of human tumors. In the hereditary childhood form of retinoblastoma, Rb is lost from chromosome 13. Rb regulates cell proliferation and differentiation by controlling progression through the restriction point within the G1 phase of the cell cycle. Rb forms complexes with many proteins, and this binding activity is required for growth suppression. Rb specifically interacts with the E2F family of transcription factors to repress E2F-mediated transcription. Rb also interacts and alters the activity of other transcription factors including Elf-1, ATF-2, MyoD, BRG-1, c-myc, N-myc. Rb recruits a histone deacetylase, HDAC1, to E2F-1 to repress transcription. Two Rb related proteins p107 and p130 also function to regulate specific members of the E2F transcription factor family.

ALT Names :

Retinoblastoma-associated protein;p105-Rb;pRb;Rb;pp110

Immunogen :

KLH-conjugated linear peptide corresponding to human Rb phosphorylated at Ser807/Ser811.

Specificity :

This antibody recognizes Rb phosphorylated at Ser807/Ser811.

Package Size :

100 μg

Uses :

Western Blotting;Cell Function Assay

Storage :

Stable for 1 year at 2-8°C from date of receipt