phospho-BRCA2 (Ser3291) Antibody | EMD Millipore AB9986 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-BRCA2 (Ser3291) Antibody

catalog :

AB9986

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, chimpanzee

application :

immunohistochemistry, immunocytochemistry, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 2	Hasvold G, Lund Andersen C, Lando M, Patzke S, Hauge S, Suo Z, et al. Hypoxia-induced alterations of G2 checkpoint regulators. Mol Oncol. 2016;10:764-73 pubmed publisher

product information

Catalog Number :

AB9986

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-BRCA2 (Ser3291) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P51587

Host Name :

Rabbit

Antigen :

phospho-BRCA2 (Ser3291)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-BRCA2 (Ser3291) Antibody

Cross Reactivity :

Human;Horse;Mouse;Rat;Chimpanzee;Canine;Hamster;Rhesus Macaque

Background :

BRCA2 (Breast Cancer Type 2 susceptibility protein) is a tumor suppressor protein encoded by the BRCA2 gene. The protein encoded by this gene plays a direct role in error-free double-strand break repair and homologous recombination. BRCA2 shares similarities with the tumor suppressor gene BRCA1. Inherited mutations in BRCA2 as well as BRCA1 are associated with an increased risk of developing breast or ovarian cancer. Although the structures of the BRCA1 and BRCA2 genes are very different, some functions are similar. The proteins made by both genes are essential for repairing damaged DNA and interact with the protein produced by the RAD51 gene. Together these three proteins play a role in maintaining the stability of the human genome and prevent dangerous gene rearrangements that can lead to the development of cancer.

ALT Names :

BRCA1/BRCA2-containing complex, subunit 2;Fanconi anemia group D1 protein 3;Fanconi anemia, complementation group D1;breast and ovarian cancer susceptibility gene, early onset;breast cancer 2 tumor suppressor;breast cancer 2, early onset;breast cancer susceptibility protein BRCA2

Immunogen :

KLH-conjugated linear peptide corresponding to human BRCA2 phosphorylated at and around the internal domain surrounding Ser3291.

Specificity :

This antibody recognizes human BRCA2 phosphorylated at and around the internal domain surrounding Ser3291.

Package Size :

100 μg

Uses :

Immunocytochemistry;Immunohistochemistry;Dot Blot

Storage :

Stable for 1 year at 2-8°C from date of receipt