Orai1 Antibody, Intracellular | EMD Millipore AB9868 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Orai1 Antibody, Intracellular

catalog :

AB9868

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig s4e	Srikanth S, Woo J, Wu B, El Sherbiny Y, Leung J, Chupradit K, et al. The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum. Nat Immunol. 2019;20:152-162 pubmed publisher

product information

Catalog Number :

AB9868

Subcategory :

Neuroscience

Product Name :

Anti-Orai1 Antibody, Intracellular

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q96D31

Host Name :

Rabbit

Antigen :

Orai1

Conjugate :

Purified

Product Description :

Anti-Orai1 Antibody, Intracellular

Cross Reactivity :

Human

Background :

TRP (transient receptor potential)-related ion channels (TRPCs) have been postulated as candidates for forming both receptor-operated (ROCE) and capacitative Ca2+ entry channels across the plasma membrane. ER transmembrane protein STIM1 senses the depletion of Ca2+ from ER stores. Orai, a regulatory β-subunit of the TRPC ion channel α-subunit, transduces the STIM1 signal into activation of the TRPC. Thus, Orai proteins by interacting with TRPCs act as regulatory subunits that confer STIM1-mediated store depletion sensitivity to these channels and regulate Ca2+ influx through the plasma membrane.

Immunogen :

Synthetic Peptide from the Intracellular domain of Orai1

Specificity :

ORai1, intracellular. Detects both the glycosylated and unglycosylated forms of ORai1. By Western blot the antibody reacts with the ~ 50 kDa ORai1 protein. Additional bands between 35 and 50 kDa may be seen if analyzing overexpressed ORai1. These additional bands most likely represent different degrees of glycosylation of ORai1

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.