NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal | EMD Millipore AB9864R product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal

catalog :

AB9864R

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

1.17.2.6

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; rat; 1:1000; loading ...; fig 5d immunohistochemistry; rat; 1:1000; loading ...; fig 4g western blot; rat; 1:1000; loading ...; fig 3a	Kim J, Ko A, Hyun H, Min S, Kim J. PDI regulates seizure activity via NMDA receptor redox in rats. Sci Rep. 2017;7:42491 pubmed publisher
immunohistochemistry; mouse; 1:250; fig s3	Watanabe Y, MÃ¼ller M, von Engelhardt J, Sprengel R, Seeburg P, Monyer H. Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation. Front Mol Neurosci. 2015;8:87 pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2a	Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-Î²-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher
immunohistochemistry; mouse; 1:1000 western blot; mouse; 1:2000	Nikitczuk J, Patil S, Matikainen Ankney B, Scarpa J, Shapiro M, Benson D, et al. N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Hippocampus. 2014;24:943-962 pubmed publisher
immunohistochemistry; mouse; 1:500	Jalewa J, Joshi A, McGinnity T, Prasad G, Wong Lin K, Holscher C. Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study. PLoS ONE. 2014;9:e88003 pubmed publisher
	Zhang J, Guan X, Li Q, Meredith A, Pan H, Yan J. Glutamate-activated BK channel complexes formed with NMDA receptors. Proc Natl Acad Sci U S A. 2018;115:E9006-E9014 pubmed publisher
	Moscato E, Peng X, Jain A, Parsons T, Dalmau J, Balice Gordon R. Acute mechanisms underlying antibody effects in anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol. 2014;76:108-19 pubmed publisher

product information

Catalog Number :

AB9864R

Subcategory :

Neuroscience

Product Name :

Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q05586

Host Name :

Rabbit

Antigen :

NMDAR1

Conjugate :

Unconjugated

Isotype :

IgG

Product Description :

Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal

Cross Reactivity :

Rat;Mouse;Human

Background :

N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) is a multi-pass membrane protein belonging to the glutamate-gated ion channel family and is one of two subunits comprising the tetrameric protein NMDAR localized throughout the brain at excitatory synapses. NMDAR1 is mediated by glycine and is a critical component to excitotoxicity, learning, memory acquisition, synaptic plasticity, and synaptogenesis. It also plays a regulatory role for neuronal functions involving glutamate neurotransmission and the targeting of NMDA receptors on the cell surface. As a glutamate-gated ion channel, NMDAR1 is highly calcium permeable and possesses sensitivity to magnesium in a voltage-dependent manner.

ALT Names :

N-methyl-D-aspartate receptor channel, subunit zeta-1;N-methyl-D-aspartate receptor subunit NR1;NMDA receptor 1;glutamate [NMDA] receptor subunit zeta 1;glutamate receptor, ionotropic, N-methyl D-aspartate 1

Immunogen :

Linear peptide corresponding to human NMDAR1.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.