Myelin Basic Protein Antibody | EMD Millipore AB980 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Myelin Basic Protein Antibody

catalog :

AB980

quantity :

500 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig s3b	Zhao T, Hong Y, Yin P, Li S, Li X. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Proc Natl Acad Sci U S A. 2017;114:E7803-E7811 pubmed publisher
immunohistochemistry - paraffin section; dogs; 1:800; fig 3	Spitzbarth I, Lempp C, Kegler K, Ulrich R, Kalkuhl A, Deschl U, et al. Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis. Brain Behav. 2016;6:e00472 pubmed publisher
immunohistochemistry - paraffin section; human; 1:250; fig 2	Wharton K, Quigley C, Themeles M, Dunstan R, Doyle K, Cahir McFarland E, et al. JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection. PLoS ONE. 2016;11:e0155897 pubmed publisher
western blot; mouse; fig 6	Huang L, Wickramasekara S, Akinyeke T, Stewart B, Jiang Y, Raber J, et al. Ion mobility-enhanced MS(E)-based label-free analysis reveals effects of low-dose radiation post contextual fear conditioning training on the mouse hippocampal proteome. J Proteomics. 2016;140:24-36 pubmed publisher
western blot; rat	Peckham H, Giuffrida L, Wood R, Gonsalvez D, Ferner A, Kilpatrick T, et al. Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination. Glia. 2016;64:255-69 pubmed publisher
	Dillenburg A, Ireland G, Holloway R, Davies C, Evans F, Swire M, et al. Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathol. 2018;135:887-906 pubmed publisher
	Newville J, Valenzuela C, Li L, Jantzie L, Cunningham L. Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder. Glia. 2017;65:1317-1332 pubmed publisher
	Zhu K, Sun J, Kang Z, Zou Z, Wu G, Wang J. Electroacupuncture Promotes Remyelination after Cuprizone Treatment by Enhancing Myelin Debris Clearance. Front Neurosci. 2016;10:613 pubmed publisher
	Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama K. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017;37: pubmed publisher
	Jung N, Park S, Choi Y, Park J, Hong Y, Park H, et al. Tonsil-Derived Mesenchymal Stem Cells Differentiate into a Schwann Cell Phenotype and Promote Peripheral Nerve Regeneration. Int J Mol Sci. 2016;17: pubmed
	Diouf B, Devaraju P, Janke L, Fan Y, Frase S, Eddins D, et al. Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion, and altered sensory function in mice. Sci Rep. 2016;6:30757 pubmed publisher
	Battefeld A, Klooster J, Kole M. Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Nat Commun. 2016;7:11298 pubmed publisher

product information

Catalog Number :

AB980

Subcategory :

Neuroscience

Product Name :

Anti-Myelin Basic Protein Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P02686

Host Name :

Rabbit

Antigen :

Myelin Basic Protein

Conjugate :

Purified

Product Description :

Anti-Myelin Basic Protein Antibody

Cross Reactivity :

Human;Mouse

Background :

The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.

ALT Names :

Myelin A1 protein;Myelin membrane encephalitogenic protein

Immunogen :

Human myelin basic protein from brain

Specificity :

Suitable for labeling of oligodendrocytes and myelin of white matter in brain and spinal cord (gray matter stains less abundantly). Also stains peripheral nerves.

Package Size :

500 µL

Uses :

Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at 2-8ºC from date of receipt.