Neurofilament L Antibody | EMD Millipore AB9568 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Neurofilament L Antibody

catalog :

AB9568

quantity :

50 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 1a, s10d	You H, Shang W, Min X, Weinreb J, Li Q, Leapman M, et al. Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer. Sci Adv. 2020;6:eaax6040 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2g	Parmhans N, Sajgo S, Niu J, Luo W, Badea T. Characterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret. J Comp Neurol. 2018;526:742-766 pubmed publisher
immunohistochemistry - frozen section; pigs ; 1:5000; loading ...; fig 2a	Kallakuri S, Desai A, Feng K, Tummala S, Saif T, Chen C, et al. Neuronal Injury and Glial Changes Are Hallmarks of Open Field Blast Exposure in Swine Frontal Lobe. PLoS ONE. 2017;12:e0169239 pubmed publisher

product information

Catalog Number :

AB9568

Subcategory :

Neuroscience

Product Name :

Anti-Neurofilament L Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P07196

Host Name :

Rabbit

Antigen :

Neurofilament L

Conjugate :

Serum

Product Description :

Anti-Neurofilament L Antibody

Cross Reactivity :

Human;Mouse;Rat;Feline;Canine;Pig;Bovine

Background :

Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10 nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexes of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments.

Immunogen :

Purified porcine NF-L

Specificity :

Recognizes Neurofilament-Light (NF-L)

Package Size :

50 µL

Uses :

Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.